Evidence map›Paper›PMID 36139808›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Novel Role of CETP in Macrophages: Reduction of Mitochondrial Oxidants Production and Modulation of Cell Immune-Metabolic Profile.

Gabriel G Dorighello, Leandro H P Assis, Thiago Rentz, Joseane Morari, Monique F M Santana, Marisa Passarelli, Neale D Ridgway, Anibal E Vercesi, Helena C F Oliveira

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  5. Association ofInternational journal of molecular sciences · 2024
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  15. Association ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gabriel G DorighelloDepartment of Pathology, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-888, SP, Brazil.
Leandro H P AssisDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas 13083-862, SP, Brazil.
Thiago RentzDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas 13083-862, SP, Brazil.
Joseane MorariObesity and Comorbidities Research Center, State University of Campinas, Campinas 13083-864, SP, Brazil.
Monique F M SantanaLaboratório de Lípides (LIM10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, SP, Brazil.ORCID 0000-0002-7380-0696
Marisa PassarelliLaboratório de Lípides (LIM10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, SP, Brazil.ORCID 0000-0002-9249-4698
Neale D RidgwayDepartments of Pediatrics, and Biochemistry and Molecular Biology, Atlantic Research Center, Dalhousie University, Halifax, NS B3H4R2, Canada.ORCID 0000-0002-0441-6228
Anibal E VercesiDepartment of Pathology, Faculty of Medical Sciences, State University of Campinas, Campinas 13083-888, SP, Brazil.
Helena C F OliveiraDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas, Campinas 13083-862, SP, Brazil.ORCID 0000-0003-0119-6992
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Nove de Julho · BRDalhousie University · CA

Funding

São Paulo Research Foundation 2013/07607-8São Paulo Research Foundation 2017/17728-8
6 · The paper itself

Abstract

Plasma cholesteryl ester transfer protein (CETP) activity diminishes HDL-cholesterol levels and thus may increase atherosclerosis risk. Experimental evidence suggests CETP may also exhibit anti-inflammatory properties, but local tissue-specific functions of CETP have not yet been clarified. Since oxidative stress and inflammation are major features of atherogenesis, we investigated whether CETP modulates macrophage oxidant production, inflammatory and metabolic profiles. Comparing macrophages from CETP-expressing transgenic mice and non-expressing littermates, we observed that CETP expression reduced mitochondrial superoxide anion production and H

Indexed as

CETPcholesterolinflammationmacrophagemitochondriaoxidants

Identifiers

PMID36139808
PMCPMC9495589
OpenAlexW4294343775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.