ArticleMolecules (Basel, Switzerland)2022
Protective Effect of
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The role of hypoglycemic phytochemicals in improving male reproductive dysfunction: a systematic review of preclinical evidence.Frontiers in endocrinology · 2026Pooled it
- Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models.Frontiers in endocrinology · 2023Pooled it
- Portulaca oleracea L. extract repairs chicken cecal barrier damage caused by Eimeria tenella.Poultry science · 2026Article
- Mechanisms of hesperetin in alleviating diabetic nephropathy: Network pharmacology, molecular docking, and experimental validation.Journal of diabetes investigation · 2026Article
- Overview of dendrimers as promising drug delivery systems with insight into anticancer and anti-microbial applications.International journal of pharmaceutics: X · 2025Review
- How Swimming Modulates Inflammatory Pathways in Pain, Neurodegenerative, and Metabolic Disorders.Brain sciences · 2025Review
- Mechanistic insights on lycopene usage against diabetes and associated complications.Journal of diabetes and metabolic disorders · 2025Review
- Molecular, cellular, and metabolic insights of cinnamon (Cinnamomum zeylanicum) advantages in diabetes and related complications: condiment or medication?Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Correction: Rakhshandeh et al. Protective Effect ofMolecules (Basel, Switzerland) · 2025Article
- Article
- Effects ofFrontiers in nutrition · 2024Article
- Article
- Hallmarks of Quercetin Benefits as a Functional Supplementary in the Management of Diabetes Mellitus-Related Maladies: From Basic to Clinical Applications.Current drug metabolism · 2024Review
- Esculeoside A alleviates reproductive toxicity in streptozotocin-diabetic rats' s model by activating Nrf2 signaling.Saudi journal of biological sciences · 2023Article
- The neuroprotective effect of traditional Chinese medicinal plants-A critical review.Acta pharmaceutica Sinica. B · 2023Review
- Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury.Nutrients · 2023Review
- Promising influences of hesperidin and hesperetin against diabetes and its complications: a systematic review of molecular, cellular, and metabolic effects.EXCLI journal · 2023Review
- Phytochemical Characteristics and Anti-Inflammatory, Immunoregulatory, and Antioxidant Effects ofEvidence-based complementary and alternative medicine : eCAM · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundType-one diabetes (T1D), a chronic autoimmune disease with marked inflammatory responses, is associated with infertility complications and implications. Based on the anti-diabetic, antioxidant, and anti-hyperlipidemic potential of
methodsMale rats were randomly divided into four experimental groups: control, diabetic, and treatment/s (PO extract at 100 or 300 mg/kg/daily). Then food and water consumption, body, testis and epididymis weights, histopathological evaluation, seminiferous tubules diameter, sperm count and motility, glucose levels, sex hormones, and inflammatory and oxidative stress markers were evaluated.
resultsOur results showed that streptozotocin-induced diabetes significantly increased food and water consumption; increased glucose, MDA, TGF-β1, and TNF-α levels; and decreased the seminiferous tubules diameter, sperm count and motility, levels of LH, testosterone, total thiol, VEGF, and SOD activity. Interestingly, PO extract (phytochemically characterized by using liquid chromatography-mass spectrometry to detect bioactive molecules) significantly ameliorated these parameters and histopathological indexes' damage in rats.
conclusionEven if more preclinical assessments are needed to better characterize the mechanism/s of action, the results of this study will pave the way for the rational use of PO on diabetic-associated clinical complications and implications.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.