Evidence map›Paper›PMID 36145545›Full record

ArticlePharmaceutics2022

Enhancement of the Bioavailability and Anti-Inflammatory Activity of Glycyrrhetinic Acid via Novel Soluplus

Hao Wang, Runwei Li, Yuan Rao, Saixing Liu, Chunhui Hu, Yong Zhang, Linchao Meng, Qilin Wu, Qiuhong Ouyang, Hao Liang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. 18β-Glycyrrhetinic Acid AttenuatesAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. SoluplusInternational journal of molecular sciences · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hao WangBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Runwei LiBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Yuan RaoBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Saixing LiuBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Chunhui HuMedical College, Qinghai University, Xining 810001, China.
Yong ZhangTechnology Corporation, Beijing 100029, China.
Linchao MengStar Health Botanical Technology Corporation, Beijing 100029, China.
Qilin WuStar Health Botanical Technology Corporation, Beijing 100029, China.
Qiuhong OuyangBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Hao LiangBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0002-4799-882X
Meng QinBeijing Advanced Innovation Centre for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Beijing University of Chemical Technology · CNQinghai University · CN

Funding

Beijing Municipal Science & Technology Commission Project No. Z171100001717024National Natural Science Foundation 52003021the National Key Research and Development Program of China 2021YFE0103500
6 · The paper itself

Abstract

Glycyrrhetinic acid (GA) is an anti-inflammatory drug with potential for development. However, the poor solubility of GA in water leads to extremely low bioavailability, which limits its clinical applications. Solid dispersions have become some of the most effective strategies for improving the solubility of poorly soluble drugs. Soluplus

Indexed as

anti-inflammatorybioavailabilitybiosafetyglycyrrhetinic acidsolid dispersionsSoluplus®

Identifiers

PMID36145545
PMCPMC9504515
OpenAlexW4293769507

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.