Evidence map›Paper›PMID 36145690›Full record

ArticlePharmaceutics2022

Role of

Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar Díaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa, Héctor Corominas

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Clinical Value ofJournal of personalized medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Luis SainzRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0001-9249-1983
Pau RieraInstitut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), 08041 Barcelona, Spain.ORCID 0000-0002-3074-3927
Patricia MoyaRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0001-8339-5420
Sara BernalInstitut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), 08041 Barcelona, Spain.ORCID 0000-0003-4427-0574
Jordi CasademontDepartment of Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.ORCID 0000-0002-8100-1827
Cesar Díaz-TornéRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Ana Milena MillánRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Hye Sang ParkRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-4972-9527
Adriana LasaInstitut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), 08041 Barcelona, Spain.ORCID 0000-0001-9957-9646
Héctor CorominasRheumatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.ORCID 0000-0002-7738-6787
Universitat Autònoma de Barcelona · ESHospital de Sant Pau · ESInstituto de Salud Carlos III · ES

Funding

Societat Catalana de Reumatologia
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic arthritis that may lead to irreversible joint damage and significant disability. Patients with RA are commonly treated with Tocilizumab (TCZ), an IL-6 receptor (IL-6R) antagonist, but many patients refractorily respond to this therapy. Identifying genetic biomarkers as predictors of TCZ response could be a key to providing a personalized medicine strategy. We aimed to evaluate whether functional single nucleotide polymorphisms (SNPs) in the

Indexed as

genetic variantsIL6Rpredictive factorsrheumatoid arthritistocilizumab

Identifiers

PMID36145690
PMCPMC9501307
OpenAlexW4296096942

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.