ArticleFrontiers in nutrition2022
Beef intake and risk of rheumatoid arthritis: Insights from a cross-sectional study and two-sample Mendelian randomization.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled it
- Article
- Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort.Diabetologia · 2026Article
- The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review.Nutrients · 2025Review
- Dietary sodium intake and all-cause mortality in rheumatoid arthritis: an NHANES analysis (2003-2018).Frontiers in nutrition · 2025Article
- Analysis of data from the NHANES 1999-2018 and Mendelian randomization studies reveals the relationship between alcohol use and rheumatoid arthritis.Nutrition journal · 2024Article
- The present understanding of the effects of dietary red meat and the Mediterranean diet on rheumatoid arthritis.Rheumatology international · 2024Article
- Diet affects inflammatory arthritis: a Mendelian randomization study of 30 dietary patterns causally associated with inflammatory arthritis.Frontiers in nutrition · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Background: Beef is common in daily diet, but its association with the risk of rheumatoid arthritis (RA) remains uncertain. The objective of this study is to explore the relationship between beef intake and the risk of RA. Materials and methods: We investigated the association between beef intake and risk of RA by multivariate logistic regression, based on the National Health and Nutrition Examination Survey (NHANES) 1999-2016 involving 9,618 participants. The dose-response relationship between beef intake and RA was explored as well. Furthermore, we performed Mendelian randomization (MR) analysis to examine the causal effect of beef intake on RA. Genetic instruments for beef intake were selected from a genome-wide association study (GWAS) including 335,576 individuals from the UK Biobank study, and summary statistics relating to RA were obtained from a GWAS meta-analysis of 14,361 RA patients and 43,923 controls. The inverse-variance weighted (IVW) approach was used to estimate the causal association, and MR-Egger regression and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test were applied to evaluate the pleiotropy and outliers. Results: Compared with the lowest quintile (0 to ≤33.50 g/d), beef intake was found to be significantly associated with the risk of RA [odds ratio (OR): 1.94; 95% confidence interval (CI): 1.20-3.12] in the third quintile (50.26 to ≤76.50 g/d). Moreover, a reversed "U" dose-response relationship between beef and RA ( Conclusion: This study indicated that there is suggestive evidence to support the causal effect of beef intake on the risk of RA, while further studies are warranted to elucidate the exact association.
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