Evidence map›Paper›PMID 36149589›Full record

ReviewCurrent heart failure reports2022

The Right Ventricle: From Embryologic Development to RV Failure.

Matthew R Lippmann, Bradley A Maron

Open access · greenAbstract readReview
In one paragraph

Review in Current heart failure reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Novel Therapies for Right Ventricular Failure.Current cardiology reports · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew R LippmannDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 77 Ave. Louis Pasteur, NRB 0630-N, Boston, MA, 02115, USA.
Bradley A MaronDivision of Cardiovascular Medicine, Brigham and Women's Hospital, 77 Ave. Louis Pasteur, NRB 0630-N, Boston, MA, 02115, USA. bmaron@bwh.harvard.edu.
Brigham and Women's Hospital · US

Funding

Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1M
NEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertensionR01HL153502 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2020 to 2023
$1.7M
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertensionR01HL155096 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R01 HL153502NHLBI NIH HHS R01 HL155096
6 · The paper itself

Abstract

purpose of reviewThe right ventricle (RV) and left ventricle (LV) have different developmental origins, which likely plays a role in their chamber-specific response to physiological and pathological stress. RV dysfunction is encountered frequently in patients with congenital heart disease (CHD) and right heart abnormalities emerge from different causes than increased afterload alone as is observed in RV dysfunction due to pulmonary hypertension (PH). In this review, we describe the developmental, structural, and functional differences between ventricles while highlighting emerging therapies for RV dysfunction. RECENT

findingsThere are new insights into the role of fibrosis, inflammation, myocyte contraction, and mitochondrial dynamics in the pathogenesis of RV dysfunction. We discuss the current state of therapies that may potentially improve RV function in both experimental and clinical trials. A clearer understanding of the differences in molecular alterations in the RV compared to the LV may allow for the development of better therapies that treat RV dysfunction.

Indexed as

Heart Defects, CongenitalHeart FailureHypertension, PulmonaryVentricular Dysfunction, RightHeart VentriclesHumansVentricular Function, RightAdult congenital heart diseaseCongenital heart diseaseLeft ventriclePulmonary hypertensionRight ventricleRight ventricular failure

Identifiers

PMID36149589
PMCPMC9818027
OpenAlexW4296794355

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.