Evidence map›Paper›PMID 36149592›Full record

ReviewCurrent osteoporosis reports2022

Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues.

Perla C Reyes Fernandez, Christian S Wright, Stuart J Warden, Julia Hum, Mary C Farach-Carson, William R Thompson

Open access · greenAbstract readReview
In one paragraph

Review in Current osteoporosis reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026
    Review
  3. Review
  4. Article
  5. Brain-Bone Axis in Physiological and Pathological Conditions.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Perla C Reyes FernandezDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA.
Christian S WrightDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA.
Stuart J WardenDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA.
Julia HumIndiana Center for Musculoskeletal Health, Indiana University, Indianapolis, IN, 46202, USA.
Mary C Farach-CarsonDepartment of Diagnostic & Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
William R ThompsonDepartment of Physical Therapy, School of Health and Human Sciences, Indiana University, Indianapolis, IN, 46202, USA. thompwil@iu.edu.ORCID 0000-0002-7022-585X
Indiana University Indianapolis · USIndiana University Health · USIndiana University – Purdue University Indianapolis · USThe University of Texas Health Science Center at Houston · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Osteocyte Mechanotransduction and the Gabapentin-Sensitive Matrix-Channel Tethering ComplexR01AR074473 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI THOMPSON, WILLIAM ROY · 2018 to 2023
$2.8M
Regulation of Skeletal Development and Mechanosensitivity by the α2δ1 Auxiliary Voltage Sensitive Calcium Channel SubunitF32AR074893 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI WRIGHT, CHRISTIAN STEPHEN · 2019 to 2021
$182k
NCATS NIH HHS UL1 TR001108NIAMS NIH HHS F32 AR074893NIAMS NIH HHS R01 AR074473NIH HHS 1F32AR074893-01NIH HHS 1R01AR074473-01
6 · The paper itself

Abstract

purpose of reviewIn this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs on the musculoskeletal system. RECENT

findingsGabapentinoids, such as gabapentin (GBP) and pregabalin (PGB) were designed as antiepileptic reagents and are now commonly used as first-line treatment for neuropathic pain and increasingly prescribed off-label for other pain disorders such as migraines and back pain. GBP and PGB exert their analgesic actions by selectively binding the α

Indexed as

CalciumGabapentingamma-Aminobutyric AcidHomeostasisHumansPregabalinCalciumGabapentingamma-Aminobutyric AcidPregabalinBoneCartilageGabapentinMusclePregabalinα2δ1

Identifiers

PMID36149592
PMCPMC10108402
OpenAlexW4296799499

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.