Evidence map›Paper›PMID 36156079›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

Associations of 24-Hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study.

Terri L Blackwell, Mariana G Figueiro, Gregory J Tranah, Jamie M Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M Kado, Kristine E Ensrud, Nancy E Lane, Yue Leng and 2 more

Abstract read
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Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Terri L BlackwellResearch Institute, California Pacific Medical Center, San Francisco, California,USA.ORCID 0000-0003-0012-7020
Mariana G FigueiroDepartment of Population Health Science and Policy, Light and Health Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gregory J TranahResearch Institute, California Pacific Medical Center, San Francisco, California,USA.
Jamie M ZeitzerDepartment of Psychiatry and Behavioral Sciences, Center for Sleep and Circadian Sciences, Stanford University, Palo Alto, California, USA.
Kristine YaffeDepartments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, California,USA.
Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-0662-8865
Deborah M KadoDepartment of Medicine, Stanford University, Stanford, California and VA Palo Alto, Palo Alto, California, USA.ORCID 0000-0002-2582-5573
Kristine E EnsrudCenter for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA.
Nancy E LaneDepartment of Medicine, Center for Musculoskeletal Health, University of California at Davis School of Medicine, Sacramento, California, USA.
Yue LengDepartment of Psychiatry, University of California, San Francisco, California,USA.
Katie L StoneResearch Institute, California Pacific Medical Center, San Francisco, California,USA.ORCID 0000-0003-2797-3171
Osteoporotic Fractures in Men (MrOS) Study Group

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Methodology Issues in a Tailored Light Treatment for Persons with DementiaR01AG034157 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI FIGUEIRO, MARIANA GROSS · 2010 to 2024
$7.9M
Outcomes of Sleep Disorders in Older Men-PortlandR01HL070838 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2003 to 2007
$1.8M
Outcomes of Sleep Disorders in Older MenR01HL070848 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 2003 to 2007
$1.6M
Outcomes of Sleep Disorders in Older Men-Palo AltoR01HL070841 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L · 2003 to 2007
$1.4M
Outcomes of Sleep Disorders in Older Men-MinneapolisR01HL070847 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 2003 to 2007
$1.3M
Outcomes of Sleep Disorders in Older Men-BirminghamR01HL070837 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2003 to 2007
$1.3M
Outcomes of Sleep Disorders in Older Men - PittsburghR01HL070842 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2003 to 2007
$1.2M
Outcomes of Sleep Disorders in Older Men- Reading CenterR01HL070839 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI REDLINE, SUSAN S. · 2003 to 2007
$1.2M
Napping, Sleep, Cognitive Decline and Risk of Alzheimer's DiseaseR00AG056598 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LENG, YUE · 2020 to 2022
$746k
NCATS NIH HHS UL1 TR000128NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NIA NIH HHS R00 AG056598NIA NIH HHS R01 AG034157NIA NIH HHS R01 AG066671NIA NIH HHS R21 AG051380
6 · The paper itself

Abstract

backgroundOlder men with the worse alignment of activity and light may have lower levels of cognition and increased rates of cognitive decline.

methodsThis cohort consisted of 1 036 older men (81.1 ± 4.6 years) from the MrOS Sleep Study (2009-2012). Light and activity levels were gathered by wrist actigraphy. Phasor analysis was used to quantify the alignment of light-dark and rest-activity patterns (magnitude) and their temporal relationship (angle). Global cognitive function (Modified Mini-Mental State examination [3MS]) and executive function (Trails B test) were measured, then repeated 4.2 ± 0.8 years later. Linear regression models examined the associations of phasor magnitude and angle with cognition and cognitive decline. Models were adjusted for age, clinic, race, education, and season.

resultsSmaller phasor magnitude (worse aligned light and activity patterns) was associated with lower initial level and increased decline in executive function. Compared to those with higher phasor magnitude, those with lower magnitude took an average of 11.1 seconds longer to complete the Trails B test (quartile 1 vs quartile 4, p = .02). After follow-up, Trails B completion time increased an average of 5.5 seconds per standard deviation decrease in phasor magnitude (95% confidence interval [CI] 0.7-10.4, p = .03). There were no associations with phasor angle, and none with magnitude and global cognition (3MS).

conclusionAmong older men, worse alignment of light and activity patterns was associated with worse initial performance and increased decline in executive function, but not related to global cognition. Interventions that improve the alignment of light and activity may slow cognitive decline in older adults.

Indexed as

Cognition DisordersCognitive DysfunctionAgedCognitionHumansMalePolysomnographySleepCircadian rhythmsCognitive functionLight exposurePhasor analysis

Identifiers

PMID36156079
PMCPMC10562886

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.