Evidence map›Paper›PMID 36158564›Full record

SynthesisFrontiers in aging neuroscience2022

Effects of rTMS treatment on global cognitive function in Alzheimer's disease: A systematic review and meta-analysis.

Tianjiao Zhang, Youxin Sui, Qian Lu, Xingjun Xu, Yi Zhu, Wenjun Dai, Ying Shen, Tong Wang

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  5. Transcranial direct current stimulation for global cognition in Alzheimer's disease: a systemic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianjiao ZhangRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Youxin SuiRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qian LuDepartment of Rehabilitation Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, China.
Xingjun XuRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi ZhuRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wenjun DaiRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ying ShenRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tong WangRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although repetitive transcranial magnetic stimulation (rTMS) has been extensively studied in patients with Alzheimer's disease (AD), the clinical evidence remains inconsistent. The purpose of this meta-analysis was to evaluate the effects of rTMS on global cognitive function in patients with AD. Methods: An integrated literature search using 4 databases (PubMed, Web of Science, Embase, and Cochrane Library) was performed to identify English language articles published up to October 6, 2021. We pooled Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) scores using a random-effects model Results: Nine studies with 361 patients were included in this meta-analysis. The results showed that rTMS significantly improved global cognitive function immediately following rTMS treatment [(MD) 1.82, 95% confidence interval (CI) 1.41-2.22, Conclusions: Repetitive TMS is a potentially effective treatment for cognitive impairment in AD that is safe and can induce long-lasting effects. Our results also showed that ADAS-cog and MMSE differed in determination of global cognitive impairment. Systematic review registration: http://www.crd.york.ac.uk/PROSPERO, PROSPERO CRD42022315545.

Indexed as

ADAS-cogAlzheimer's diseasecognitive functionmeta-analysisMMSErepetitive transcranial magnetic stimulation (rTMS)systematic review

Identifiers

PMID36158564
PMCPMC9492846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.