Evidence map›Paper›PMID 36158666›Full record

ArticleFrontiers in oncology2022

Four methylation-driven genes detected by linear discriminant analysis model from early-stage colorectal cancer and their methylation levels in cell-free DNA.

Lei Zhan, Changjian Sun, Yu Zhang, Yue Zhang, Yuzhe Jia, Xiaoyan Wang, Feifei Li, Donglin Li, Shen Wang, Tao Yu and 2 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Correlation analysis of the impact ofMicrobiology spectrum · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei ZhanMedical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, China.
Changjian SunClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Yu ZhangClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Yue ZhangClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Yuzhe JiaClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Xiaoyan WangClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Feifei LiMedical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, China.
Donglin LiOrthopedics Department, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Shen WangDepartment of Ultrasound and Special Diagnosis, Air Force Hospital of Northern Theater, PLA, Shenyang, China.
Tao YuNursing Department, Air Force Medical Center, PLA, Beijing, China.
Jingdong ZhangMedical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, China.
Deyang LiClinical Laboratory, Air Force Hospital of Northern Theater, PLA, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of colorectal cancer (CRC) formation is considered a typical model of multistage carcinogenesis in which aberrant DNA methylation plays an important role. In this study, 752 methylation-driven genes (MDGs) were identified by the

Indexed as

carcinogenesiscell-free DNA - cfDNAcolorectal cancerDNA Methylationlinear discriminant analysis

Identifiers

PMID36158666
PMCPMC9491101

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.