Evidence map›Paper›PMID 36160709›Full record

ArticleOxidative medicine and cellular longevity2022

Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism.

Suwen Wu, Yutong Cui, Huanqiang Zhao, Xirong Xiao, Lili Gong, Huangfang Xu, Qiongjie Zhou, Duan Ma, Xiaotian Li

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Trophoblast adaptation to hypoxia: balance and dysfunction.Cell communication and signaling : CCS · 2025
    Review
  4. Review
  5. Functions of RhoA in the female reproductive system.Reproductive and developmental medicine · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Endogenous retrovirus HERVH-derived lncRNAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suwen WuObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2772-6480
Yutong CuiObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-5929-5101
Huanqiang ZhaoObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-3664-8031
Xirong XiaoObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2808-2314
Lili GongObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4766-9145
Huangfang XuObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2929-8790
Qiongjie ZhouObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-1264-161X
Duan MaKey Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-3089-0967
Xiaotian LiObstetrics and Gynecology Hospital of Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2051-4581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia is regarded as an evolution-related disease that has only been observed in humans and our closest relatives, and the important factor contributing to its pathogenesis is endothelial dysregulation secondary to a stressed placenta. Hypoxia-inducible factor 1 subunit alpha (HIF1

Indexed as

Pre-EclampsiaRNA, Long NoncodingUrinary Bladder NeoplasmsDeubiquitinating EnzymesEndothelial CellsFemaleHumansHypoxiaHypoxia-Inducible Factor 1PlacentaPregnancyProfilinsReactive Oxygen SpeciesrhoA GTP-Binding Proteinrho-Associated KinasesTrophoblastsDeubiquitinating EnzymesHypoxia-Inducible Factor 1PFN1 protein, humanProfilinsReactive Oxygen SpeciesrhoA GTP-Binding ProteinRHOA protein, humanrho-Associated KinasesRNA, Long NoncodingUbiquitin-Specific ProteasesUbiquitin ThiolesteraseUCA1 RNA, humanUSP14 protein, humanVascular Endothelial Growth Factor A

Identifiers

PMID36160709
PMCPMC9499815

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.