Evidence map›Paper›PMID 36161920›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex.

Aidan L Huene, Steven M Sanders, Zhiwei Ma, Anh-Dao Nguyen, Sergey Koren, Manuel H Michaca, James C Mullikin, Adam M Phillippy, Christine E Schnitzler, Andreas D Baxevanis and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. A chromosome-level genome assembly for the colonial marine hydrozoanbioRxiv : the preprint server for biology · 2026
    Article
  3. Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. The genome of the colonial hydroidGenome research · 2024
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aidan L HueneThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Steven M SandersThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Zhiwei MaThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-5385-6695
Anh-Dao NguyenComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
Sergey KorenComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.ORCID 0000-0002-1472-8962
Manuel H MichacaThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261.
James C MullikinComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.ORCID 0000-0003-0825-3750
Adam M PhillippyComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.ORCID 0000-0003-2983-8934
Christine E SchnitzlerWhitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, FL 32080.ORCID 0000-0002-5001-6524
Andreas D BaxevanisComputational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892.ORCID 0000-0002-5370-0014
Matthew L NicotraThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-5361-8398
National Human Genome Research Institute · USUniversity of Pittsburgh · USWhitney Museum of American Art · US

Funding

Single-molecule sequence assembly and analysisZIAHG200398 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PHILLIPPY, ADAM · 2016 to 2025
$15.9M
Phylogenomic Studies on the Evolution of Morphological ComplexityZIAHG000140 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAXEVANIS, ANDREAS · 2009 to 2025
$11.4M
Interdisciplinary Training in Transplantation BiologyT32AI074490 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Angus W Thomson · 2007 to 2026
$4.2M
Characterizing the molecular regulators of stem cell populations during homeostasis and regeneration in Hydractinia, an emerging cnidarianresearch organism; Administrative SupplementsR35GM138156 · NIGMS · UNIVERSITY OF FLORIDA · PI SCHNITZLER, CHRISTINE · 2020 to 2024
$1.9M
Intramural NIH HHS ZIA HG000140Intramural NIH HHS ZIA HG200398NIAID NIH HHS T32 AI074490NIGMS NIH HHS R35 GM138156
6 · The paper itself

Abstract

Most colonial marine invertebrates are capable of allorecognition, the ability to distinguish between themselves and conspecifics. One long-standing question is whether invertebrate allorecognition genes are homologous to vertebrate histocompatibility genes. In the cnidarian

Indexed as

HydrozoaImmunoglobulinsMajor Histocompatibility ComplexAnimalsMembrane ProteinsProtein DomainsTyrosineImmunoglobulinsMembrane ProteinsTyrosineallorecognitionAlphaFoldgene complexHydractinianonself recognition

Identifiers

PMID36161920
PMCPMC9546547
OpenAlexW4297092690

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.