Evidence map›Paper›PMID 36164711›Full record

ArticleAnnals of medicine2022

Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation.

Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mostafa Said, Hesham Elkassar, Mohammad El Sherbiny, Ahmed Youssef, Mohammed Elbaz, Ahmed M Elmeligui, Mohamed Badr Hassan, Mahmoud Gouda Omar and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Ahmed Abdallah SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-0026-0841
Mohamed Abdalla SalmanGeneral Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mostafa SaidInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hesham ElkassarInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohammad El SherbinyInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed YoussefInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohammed ElbazInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed M ElmeliguiInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Badr HassanInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mahmoud Gouda OmarInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0001-9743-4398
Hussien SamirInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Abdelkader MoradInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hossam El-Din ShaabanGastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Mohamed YoussefDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed MoustafaDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Sabry TourkyDepartment of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK.
Ahmed ElewaGeneral Surgery Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Sadaf KhalidGeneral Surgery Department, Royal Free Hospital, London, UK.
Khaled MonazeaGeneral Surgery Department, Assiut Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.
Mohamed ShawkatInternal Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt.
Cairo University · EGResearch Institute for Tropical Medicine · PHAl-Azhar University · EGGreat Western Hospital · GBMinia University · EGThe Royal Free Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in patients with pre-existing DM.

methodsThis retrospective study involved 103 type II diabetic patients with end-stage liver disease who received LDLT. Preoperative spot urine albumin: creatinine ratio was used to determine the degree of albuminuria. The primary outcome measure was the impact of urinary albumin excretion on the 3-year mortality rate after LDLT in this diabetic cohort.

resultsHepatitis C virus infection was the main cause of cirrhosis. Albuminuria was detected in 41 patients (39.8%); 15 had macroalbuminuria, while 26 had microalbuminuria. Patients with microalbuminuria were significantly older than those with macroalbuminuria and normal albumin in urine. After 3 years, twenty-four patients (23.3%) died within 3 years after LT. Myocardial infarction was the leading cause of death (25%). Albuminuria was an independent factor affecting 3-year mortality with an odds ratio of 5.17 (95% CI: 1.86-14.35).

conclusionPreoperative albuminuria is an independent factor affecting mortality within 3 years after LDLT in type II diabetic patients. Myocardial infarction was the leading cause of death in 25% of cases, followed by hepatocellular carcinoma recurrence, sepsis, and graft failure.KEY MESSAGESDiabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection.Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality.Preoperative albuminuria is a significant predictor of mortality within 3 years after LDLT in diabetic patients.

Indexed as

Acute-On-Chronic Liver FailureAlbuminuriaDiabetes Mellitus, Type 2Liver TransplantationCreatinineHumansLiving DonorsMyocardial InfarctionRetrospective StudiesCreatininealbuminuriadiabetesLiver transplant

Identifiers

PMID36164711
PMCPMC9521493
OpenAlexW4297255311

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.