ArticleScience signaling2022
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.
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In one paragraph
Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development.iScience · 2026Article
- Inhibition of PKCγ phosphorylation protects against cerebral ischemia-reperfusion injury.Redox biology · 2026Article
- Sex-specific disruptions in PKCγ signaling in a mouse model of spinocerebellar ataxia type 14.JCI insight · 2026Article
- Familial SCA14: A case report with review.Experimental and therapeutic medicine · 2026Article
- PKCγ-mediated Phosphorylation of Mtss1 Regulates the Dendritic Outgrowth and Spine Development of Cerebellar Purkinje Cells.Molecular neurobiology · 2025Article
- Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.MedComm · 2025Review
- A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.Science signaling · 2025Article
- Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.medRxiv : the preprint server for health sciences · 2025Article
- Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery.Signal transduction and targeted therapy · 2025Review
- Novel C1A Domain Variant in Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Decreases Autoinhibition.Cerebellum (London, England) · 2025Article
- Advancements in Protein Kinase Inhibitors: From Discovery to Clinical Applications.Research (Washington, D.C.) · 2025Review
- Cancer-associated mutations in protein kinase C theta are loss-of-function.The Biochemical journal · 2024Article
- A selective review of inhibitors of protein kinase C gamma: a neuroplasticity-related common pathway for psychiatric illness.Frontiers in drug delivery · 2024Review
- Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.The Biochemical journal · 2023Article
- Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss.Frontiers in molecular neuroscience · 2023Review
- Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Caila A PiloDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-5730-9995
Timothy R BaffiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0003-2862-6155
Alexandr P KornevDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-1543-3795
Maya T KunkelDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-0027-5149
Mario MalfavonDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-0180-4006
Dong-Hui ChenDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-2584-8609
Leigh-Ana RossittoDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-7744-3630
Daniel X ChenDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5496-1198
Liang-Chin HuangInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-5661-8940
Cheryl LongmanQueen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK.
Natarajan KannanInstitute of Bioinformatics, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-2833-8375
Wendy H RaskindDepartment of Medicine/Medical Genetics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-8141-9054
David J GonzalezDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0003-1423-5970
Susan S TaylorDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-7702-6108
George GorrieQueen Elizabeth University Hospital, Glasgow, Scotland G51 4TF, UK.ORCID 0000-0001-9574-6486
Alexandra C NewtonDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.ORCID 0000-0002-2906-3705
University of California San Diego · USUniversity of Washington · USQueen Elizabeth University Hospital · GBUniversity of Georgia · US
Funding
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5MMolecular Mechanisms of Cell SignalingR35GM122523 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDRA C. NEWTON · 2017 to 2026
$6.7MLessons Learned from PKA: Assembly of Dynamic Macromolecular SwitchesR35GM130389 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN S. TAYLOR · 2019 to 2026
$5.7MNext Generation gene discovery in neurogeneticsR01NS069719 · NINDS · UNIVERSITY OF WASHINGTON · PI RASKIND, WENDY H · 2010 to 2019
$5.0MStructural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar AtaxiaR01NS120725 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDRA C. NEWTON, SUSAN S. TAYLOR · 2021 to 2026
$3.9MUnlocking sequence-structure-function-disease relationships in large protein super-familiesR35GM139656 · NIGMS · UNIVERSITY OF GEORGIA · PI KANNAN, NATARAJAN · 2021 to 2025
$2.2MNIGMS NIH HHS R35 GM122523NIGMS NIH HHS R35 GM130389NIGMS NIH HHS R35 GM139656NIGMS NIH HHS T32 GM007752NINDS NIH HHS R01 NS069719NINDS NIH HHS R01 NS120725
Abstract
Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disease caused by germline variants in the diacylglycerol (DAG)/Ca
Indexed as
DiglyceridesSpinocerebellar AtaxiasAnimalsHumansMiceMutationProtein Kinase CPurkinje CellsDiglyceridesProtein Kinase Cprotein kinase C gamma
Identifiers
What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.