Evidence map›Paper›PMID 36172386›Full record

ArticleFrontiers in immunology2022

Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein.

Jia Tong Loh, Joey Kay Hui Teo, Kong-Peng Lam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. TLRs: Innate Immune Sentries against SARS-CoV-2 Infection.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jia Tong LohSingapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
Joey Kay Hui TeoSingapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
Kong-Peng LamSingapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore.
Agency for Science, Technology and Research · SGNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased neutrophils and elevated level of circulating calprotectin are hallmarks of severe COVID-19 and they contribute to the dysregulated immune responses and cytokine storm in susceptible patients. However, the precise mechanism controlling calprotectin production during SARS-CoV-2 infection remains elusive. In this study, we showed that Dok3 adaptor restrains calprotectin production by neutrophils in response to SARS-CoV-2 spike (S) protein engagement of TLR4. Dok3 recruits SHP-2 to mediate the de-phosphorylation of MyD88 at Y257, thereby attenuating downstream JAK2-STAT3 signaling and calprotectin production. Blocking of TLR4, JAK2 and STAT3 signaling could prevent excessive production of calprotectin by Dok3

Indexed as

Adaptor Proteins, Signal TransducingCOVID-19Spike Glycoprotein, CoronavirusHumansLeukocyte L1 Antigen ComplexMyeloid Differentiation Factor 88NeutrophilsSARS-CoV-2Toll-Like Receptor 4Adaptor Proteins, Signal TransducingDOK3 protein, humanLeukocyte L1 Antigen ComplexMyeloid Differentiation Factor 88Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TLR4 protein, humanToll-Like Receptor 4calprotectinDok3neutrophilsSARS-CoV-2TLR4

Identifiers

PMID36172386
PMCPMC9510782
OpenAlexW4297872394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.