Trial reportDiabetes technology & therapeutics2022
A Multicenter Randomized Trial Evaluating the Insulin-Only Configuration of the Bionic Pancreas in Adults with Type 1 Diabetes.
Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Diabetes technology & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04200313 (The Insulin-Only Bionic Pancreas Pivotal Trial), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Insulin-Only Bionic Pancreas Pivotal Trial: Testing the iLet in Adults and Children With Type 1 Diabetes
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Glycaemic control and variability with different commercially available hybrid closed loop systems in people with type 1 diabetes: A systematic review and meta-analysis of randomized controlled trials.Diabetes, obesity & metabolism · 2026Pooled it
- Efficacy and Safety of iLet Bionic Pancreas in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta Analysis.Endocrinology, diabetes & metabolism · 2025Pooled it
- Real-World Evidence of Automated Insulin Delivery System Use.Diabetes technology & therapeutics · 2024Pooled it
- Trial
- Psychometric Properties of the Automated Insulin Delivery: Benefits and Burdens Scale for Adults with Type 1 Diabetes.Diabetes technology & therapeutics · 2024Trial
- Randomized Trial of the Insulin-Only iLet Bionic Pancreas for the Treatment of Cystic Fibrosis- Related Diabetes.Diabetes care · 2024Trial
- Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study.Diabetes technology & therapeutics · 2023Trial
- The Insulin-Only Bionic Pancreas Improves Glycemic Control in Non-Hispanic White and Minority Adults and Children With Type 1 Diabetes.Diabetes care · 2023Trial
- The Insulin-Only Bionic Pancreas Pivotal Trial Extension Study: A Multi-Center Single-Arm Evaluation of the Insulin-Only Configuration of the Bionic Pancreas in Adults and Youth with Type 1 Diabetes.Diabetes technology & therapeutics · 2022Trial
- Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes.The New England journal of medicine · 2022Trial
- Worsening of diabetic retinopathy with initiation of an automated insulin delivery system.American journal of ophthalmology case reports · 2026Article
- Diabetic cardiomyopathy: a comprehensive review of diagnosis, management, and future directions.Diabetology & metabolic syndrome · 2025Review
- App-based automated meal analysis in adults with type 1 diabetes using automated insulin delivery: a randomized controlled trial.EClinicalMedicine · 2025Article
- Registration and Real-Life Studies on Automated Insulin Delivery Systems.Journal of diabetes science and technology · 2025Review
- 7. Diabetes Technology: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Dosing Algorithms for Insulin Pumps.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Safety and Feasibility Evaluation of Automated User Profile Settings Initialization and Adaptation With Control-IQ Technology.Journal of diabetes science and technology · 2024Article
- Advances in diabetes technology to improve the lives of people with cystic fibrosis.Diabetologia · 2024Review
- 7. Diabetes Technology: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Utility and precision evidence of technology in the treatment of type 1 diabetes: a systematic review.Communications medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 12 institutions in 1 country.
Davida KrugerHenry Ford Health System, Detroit, Michigan, USA.
Alex KassDivision of Endocrinology & Metabolism, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Jacqueline LonierNaomi Berrie Diabetes Center, Columbia University, New York City, New York, USA.
Jeremy PettusDepartment of Medicine, University of California, San Diego, California, USA.
Philip RaskinDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Maamoun SalamDivision of Endocrinology, Metabolism & Lipid Research, John T. Miller Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Subbulaxmi TrikudanathanDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA.
Keren ZhouCleveland Clinic, Cleveland, Ohio, USA.
Steven J RussellDiabetes Research Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8423-5891
Edward R DamianoDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
Firas H El-KhatibBeta Bionics, Concord, Massachusetts, USA.
Katrina J RuedyJaeb Center for Health Research, Tampa, Florida, USA.
Courtney BalliroDiabetes Research Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Zoey LiJaeb Center for Health Research, Tampa, Florida, USA.
Martin Chase MarakJaeb Center for Health Research, Tampa, Florida, USA.
Peter CalhounJaeb Center for Health Research, Tampa, Florida, USA.ORCID 0000-0002-5325-7200
Roy W BeckJaeb Center for Health Research, Tampa, Florida, USA.ORCID 0000-0002-5325-7200
Jaeb Center for Health Research · USMassachusetts General Hospital · USBoston University · USCity University of New York · USCleveland Clinic · USConcord Consortium · USHenry Ford Health System · USThe University of Texas Southwestern Medical Center · USUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USWashington University in St. Louis · US
Funding
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MFinal clinical studies for submission of a pre-market approval application to the FDA for a Bionic Pancreas that automates type 1 diabetes managementUC4DK108612 · NIDDK · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BECK, ROY W., DAMIANO, EDWARD · 2015 to 2016
$13.5MPilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0MNCATS NIH HHS UL1 TR002489NIDDK NIH HHS P30 DK124723NIDDK NIH HHS UC4 DK108612
Abstract
PubMed holds no abstract for this paper.
Indexed as
Diabetes Mellitus, Type 1HypoglycemiaAdolescentAdultAgedBionicsBlood GlucoseBlood Glucose Self-MonitoringGlycated HemoglobinHumansHypoglycemic AgentsInsulinInsulin AspartInsulin LisproInsulin, Regular, HumanMiddle AgedBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinInsulin AspartInsulin LisproInsulin, Regular, HumanAdultArtificial pancreasAutomated insulin deliveryBionic pancreasEvaluationtype 1 diabetes
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
NCT04200313ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.