ArticleNature communications2022
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Pooled it
- Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS-CoV-2 P.1 Variant in K18-hACE2 Mice.Immunity, inflammation and disease · 2026Article
- CT-adipose measures identify severe SARS-CoV-2 risk beyond traditional obesity metrics: a C4R cohort study.BMC pulmonary medicine · 2026Article
- Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update.Obesity (Silver Spring, Md.) · 2026Review
- SARS-CoV-2-infected adipocytes drive adipose inflammation and hepatocyte lipid accumulation.Frontiers in immunology · 2026Article
- Article
- The impact of diabetes and obesity on the severity and mortality of SARS-CoV-2 infection.Journal of diabetes and metabolic disorders · 2025Review
- Alpha Linolenic and Stearic Acids Modulate Genes Related to Viral Entry and Inflammatory Response in THP-1 Derived Macrophages Exposed to SARS-CoV-2.Food science & nutrition · 2025Article
- Article
- Impact of Obesity and Ageing on the Expression of Key Mediators of SARS-CoV-2 Infection in Human Adipose Tissue.International journal of molecular sciences · 2025Article
- Article
- Adult Long Coronavirus Disease 2019: Definition, Prevalence Pathophysiology, and Clinical Manifestations.Infectious disease clinics of North America · 2025Review
- From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection.The FEBS journal · 2025Review
- Pre-existing adipose tissue signaling profile related to obesity determines disease outcome of COVID-19: addressing obesity should be a priority for future pandemic preparedness.Frontiers in endocrinology · 2025Article
- The economic impacts of COVID-19 hospitalizations, intensive care unit admissions, and deaths related to overweight and obesity.PLOS global public health · 2025Article
- Upregulation of inflammatory genes and pathways links obesity to severe COVID-19.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- IL-1β promotes adipogenesis by directly targeting adipocyte precursors.Nature communications · 2024Article
- Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism.Biomedicines · 2024Review
- Body fat predicts urinary tract infection in kidney transplant recipients: a prospective cohort study.Journal of nephrology · 2024Article
- The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health.GeroScience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 7 institutions in 3 countries.
Tatiana Dandolini Saccon *Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Felippe Mousovich-Neto *Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-8245-9450
Raissa Guimarães Ludwig *Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Victor Corasolla Carregari *Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Ana Beatriz Dos Anjos Souza *Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Amanda Stephane Cruz Dos Passos *Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID 0000-0001-6072-1721
Matheus Cavalheiro MartiniDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Priscilla Paschoal BarbosaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Gabriela Fabiano de SouzaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Stéfanie Primon MuraroDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-5105-6659
Julia ForatoDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Mariene Ribeiro AmorimDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Rafael Elias MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil.ORCID 0000-0002-6949-0947
Flavio Protasio VerasDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Ester BarretoDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID 0000-0002-1982-5841
Tiago Tomazini GonçalvesCenter for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.ORCID 0000-0002-7503-6062
Isadora Marques PaivaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID 0000-0002-2741-150X
Narayana P B FazoliniDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Carolina Mie Kawagosi OnoderaHematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
Ronaldo Bragança Martins JuniorVirology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Paulo Henrique Cavalcanti de AraújoDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Sabrina Setembre BatahDepartment of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Rosa Maria Mendes VianaVirology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Danilo Machado de MeloVirology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Alexandre Todorovic FabroDepartment of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Eurico ArrudaVirology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Fernando Queiroz CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Thiago Mattar CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID 0000-0003-1084-0065
Marco Antônio M PrettiLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.ORCID 0000-0002-9511-294X
Bradley Joseph SmithDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Henrique Marques-SouzaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-5008-8413
Thiago L KnittelDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Gabriel Palermo RuizDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Gerson S ProfetaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Tereza Cristina Minto Fontes-CalDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Mariana BoroniLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Marco Aurélio Ramirez VinoloDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.
Alessandro S FariasDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0001-6759-1819
Pedro Manoel M Moraes-VieiraDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-8263-786X
Joyce Maria Annichino BizzacchiHematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil.
Tambet TeesaluLaboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Felipe David Mendonça ChaimDepartment of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-4195-6143
Everton CazzoDepartment of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Elinton Adami ChaimDepartment of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
José Luiz Proença-MódenaDepartment of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.ORCID 0000-0002-4996-3153
Daniel Martins-de-SouzaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. dmsouza@unicamp.br.ORCID 0000-0003-3595-5846
Mariana Kiomy OsakoDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. mko@fmrp.usp.br.ORCID 0000-0002-5021-8433
Luiz Osório LeiriaDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. luizleiria@usp.br.ORCID 0000-0001-9483-3705
Marcelo A MoriDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. morima@unicamp.br.ORCID 0000-0001-7112-5263
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BRUniversidade de Ribeirão Preto · BRBrazilian Center for Research in Energy and Materials · BRInstituto Nacional de Câncer - INCA · BRNational Council for Scientific and Technological Development · BRUniversity of Tartu · EE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage. Visceral fat cells express more ACE2 and are more susceptible to SARS-CoV-2 infection than their subcutaneous counterparts. SARS-CoV-2 infection leads to inhibition of lipolysis in subcutaneous fat cells, while in visceral fat cells, it results in higher expression of pro-inflammatory cytokines. Viral load and cellular response are attenuated when visceral fat cells are infected with the SARS-CoV-2 gamma variant. A similar degree of cell death occurs 4-days after SARS-CoV-2 infection, regardless of the cell origin or viral lineage. Hence, SARS-CoV-2 infects human fat cells, replicating and altering cell function and viability in a depot- and viral lineage-dependent fashion.
Indexed as
COVID-19SARS-CoV-2Adipose TissueAngiotensin-Converting Enzyme 2CytokinesHumansAngiotensin-Converting Enzyme 2Cytokines
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.