Evidence map›Paper›PMID 36178169›Full record

Trial reportJournal of dietary supplements2023

Hepatotoxicity with High-Dose Green Tea Extract: Effect of

Laura Acosta, Laura Byham-Gray, Mindy Kurzer, Hamed Samavat

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of dietary supplements, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Laura AcostaDepartment of Clinical and Preventive Nutrition Sciences, Rutgers University School of Health Professions, Newark, NJ, USA.
Laura Byham-GrayDepartment of Clinical and Preventive Nutrition Sciences, Rutgers University School of Health Professions, Newark, NJ, USA.ORCID 0000-0002-0316-2086
Mindy KurzerDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.ORCID 0000-0003-2191-6459
Hamed SamavatDepartment of Clinical and Preventive Nutrition Sciences, Rutgers University School of Health Professions, Newark, NJ, USA.ORCID 0000-0002-3545-1712
Rutgers, The State University of New Jersey · USUniversity of Minnesota · US

Funding

Green Tea and Reduction of Breast Cancer RiskR01CA127236 · NCI · UNIVERSITY OF MINNESOTA · PI KURZER, MINDY SUSAN · 2008 to 2013
$5.7M
NCI NIH HHS R01 CA127236
6 · The paper itself

Abstract

The predominant catechin in green tea, epigallocatechin gallate (EGCG), may be hepatotoxic in high doses. Our objective was to investigate the influence of

Indexed as

CatechinChemical and Drug Induced Liver InjuryPlant ExtractsAntioxidantsCatechol O-MethyltransferaseDietary SupplementsFemaleGenotypeGlucuronosyltransferaseHumansTeaAntioxidantsbilirubin glucuronoside glucuronosyltransferaseCatechinCatechol O-MethyltransferaseCOMT protein, humanGlucuronosyltransferasePlant ExtractsTeaalanine transaminaseaspartate aminotransferasesCamellia sinensiscatechol O-methyltransferasechemical and drug induced liver injuryepigallocatechin gallateglucuronosyltransferasetea

Identifiers

PMID36178169
PMCPMC10060436
OpenAlexW4298087365

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.