Evidence map›Paper›PMID 36180572›Full record

ArticleScientific reports2022

SNP discovery and association study for growth, fatness and meat quality traits in Iberian crossbred pigs.

C Óvilo, N Trakooljul, Y Núñez, F Hadlich, E Murani, M Ayuso, C García-Contreras, M Vázquez-Gómez, A I Rey, F Garcia and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

C ÓviloDepartamento Mejora Genética Animal, INIA-CSIC, Madrid, Spain. ovilo@inia.csic.es.
N TrakooljulResearch Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
Y NúñezDepartamento Mejora Genética Animal, INIA-CSIC, Madrid, Spain.
F HadlichResearch Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
E MuraniResearch Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
M AyusoCoPeD, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
C García-ContrerasDepartment of Nutrition and Sustainable Animal Production, CSIC, Granada, Spain.
M Vázquez-GómezSorbonne Université, INSERM, NutiOmique, Paris, France.
A I ReyDepartamento de Producción Animal, Facultad de Veterinaria, UCM, Madrid, Spain.
F GarciaDepartamento Mejora Genética Animal, INIA-CSIC, Madrid, Spain.
J M García-CascoDepartamento Mejora Genética Animal, INIA-CSIC, Madrid, Spain.
C López-BoteDepartamento de Producción Animal, Facultad de Veterinaria, UCM, Madrid, Spain.
B IsabelDepartamento de Producción Animal, Facultad de Veterinaria, UCM, Madrid, Spain.
A González-BulnesFacultad de Medicina Veterinaria, Universidad Cardenal Herrera-CEU, Valencia, Spain.
K WimmersResearch Institute for Farm Animal Biology, FBN, Dummerstorf, Germany.
M MuñozDepartamento Mejora Genética Animal, INIA-CSIC, Madrid, Spain.
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESResearch Institute for Farm Animal Biology (FBN) · DEUniversidad Complutense de Madrid · ESConsejo Superior de Investigaciones Científicas · ESInserm · FRUniversidad Cardenal Herrera CEU · ESUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iberian pigs and its crosses are produced to obtain high-quality meat products. The objective of this work was to evaluate a wide panel of DNA markers, selected by biological and functional criteria, for association with traits related to muscle growth, fatness, meat quality and metabolism. We used 18 crossbred Iberian pigs with divergent postnatal growth patterns for whole genome sequencing and SNP discovery, with over 13 million variants being detected. We selected 1023 missense SNPs located on annotated genes and showing different allele frequencies between pigs with makerdly different growth patterns. We complemented this panel with 192 candidate SNPs obtained from literature mining and from muscle RNAseq data. The selected markers were genotyped in 480 Iberian × Duroc pigs from a commercial population, in which phenotypes were obtained, and an association study was performed for the 1005 successfully genotyped SNPs showing segregation. The results confirmed the effects of several known SNPs in candidate genes (such as LEPR, ACACA, FTO, LIPE or SCD on fatness, growth and fatty acid composition) and also disclosed interesting effects of new SNPs in less known genes such as LRIG3, DENND1B, SOWAHB, EPHX1 or NFE2L2 affecting body weight, average daily gain and adiposity at different ages, or KRT10, NLE1, KCNH2 or AHNAK affecting fatness and FA composition. The results provide a valuable basis for future implementation of marker-assisted selection strategies in swine and contribute to a better understanding of the genetic architecture of relevant traits.

Indexed as

MeatPolymorphism, Single NucleotideAnimalsFatty AcidsGenetic MarkersGenome-Wide Association StudyPhenotypeSwineFatty AcidsGenetic Markers

Identifiers

PMID36180572
PMCPMC9525691
OpenAlexW4298142934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.