Evidence map›Paper›PMID 36188151›Full record

ArticleWorld journal of diabetes2022

Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics.

Bing-Wei Li, Yuan Li, Xu Zhang, Sun-Jing Fu, Bing Wang, Xiao-Yan Zhang, Xue-Ting Liu, Qin Wang, Ai-Ling Li, Ming-Ming Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bing-Wei LiInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Yuan LiInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Xu ZhangLaboratory of Electron Microscopy, Ultrastructural Pathology Center, Peking University First Hospital, Beijing 100005, China.
Sun-Jing FuInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Bing WangInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Xiao-Yan ZhangInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Xue-Ting LiuInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Qin WangInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Ai-Ling LiInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Ming-Ming LiuInstitute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China. mingmingliu@imc.pumc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pancreatic islet microcirculation adapts its metabolism to cope with limited oxygen availability and nutrient delivery. In diabetes, the balance between oxygen delivery and consumption is impaired. Insulin has been proven to exert complex actions promoting the maintenance of homeostasis of the pancreas under glucotoxicity.

aimTo test the hypothesis that insulin administration can improve the integrated pancreatic microcirculatory oxygen profile and bioenergetics.

methodsThe pancreatic microcirculatory partial oxygen pressure (PO

resultsSignificantly lower PO

conclusionGlucotoxicity deteriorates the integrated pancreatic microcirculatory oxygen profile and bioenergetics, but this deterioration can be reversed by insulin administration.

Indexed as

BioenergeticsDiabetes mellitusEndothelial cellsGlucotoxicityMicrocirculationMitochondria

Identifiers

PMID36188151
PMCPMC9521437

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.