ArticleDevelopment and psychopathology2024
Social motivation in infancy is associated with familial recurrence of ASD.
Article in Development and psychopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Mitigating Sex-Related Biases to Elucidate the Autism Phenotype.Biological psychiatry · 2026Review
- Parsing the heterogeneity of social motivation in autism.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Social motivation by self- and caregiver-report: Reporter concordance and social correlates among autistic and neurotypical youth.Autism research : official journal of the International Society for Autism Research · 2024Article
- Quantifying latent social motivation and its associations with joint attention and language in infants at high and low likelihood for autism spectrum disorder.Developmental science · 2023Article
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Authors and funding
16 authors at 7 institutions in 2 countries.
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Abstract
Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation's course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation's importance to risk assessment and clarification of the ontogeny of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.