Evidence map›Paper›PMID 36191639›Full record

ArticleGastroenterology2023

Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression.

Dongni Fu, Brandon M Blobner, Phil J Greer, Robert Lafyatis, Melena D Bellin, David C Whitcomb, Prospective Autos Study, GREAT1 Study, North American Pancreatitis Study Group

Open access · bronzeAbstract readLetter
In one paragraph

Article in Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dongni FuDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Brandon M BlobnerDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Phil J GreerDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Robert LafyatisDivision of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Melena D BellinDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
David C WhitcombDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine and, Department of Cell Biology and Molecular Physiology, and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: whitcomb@pitt.edu.
Prospective Autos Study
GREAT1 Study
North American Pancreatitis Study Group
University of Pittsburgh · USUniversity of Minnesota · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
MOLECULAR STUDIES IN NONSYNDROMIC CLEFT LIP AND PALATER01DE011931 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLANTON, SUSAN HALLORAN, HECHT, JACQUELINE T · 1999 to 2017
$7.6M
UPMC Clinical Center for the Study of Chronic Pancreatitis and DiabetesU01DK108306 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Frederico G. S. Toledo, Dhiraj Yadav · 2015 to 2026
$6.4M
Digestive Diseases Training ProgramT32DK063922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARTEEL, GAVIN E, YADAV, DHIRAJ · 2003 to 2022
$5.2M
North American Pancreatitis Study 2 (NAPS2)R01DK061451 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 2002 to 2010
$4.9M
NAPS2-AS: Race Dependent Risk for PancreatitisR01DK077906 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YADAV, DHIRAJ · 2010 to 2013
$2.3M
3D Analysis of Normal Facial Variation: Data Repository and Genetics (Research)U01DE020078 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2009 to 2013
$2.0M
Health outcomes and improved phenotypic characterization of cleft lip and palateR01DD000295 · DD · UNIVERSITY OF IOWA · PI WEHBY, GEORGE L · 2007 to 2009
$1.4M
NAPS2 Continuation Genome Wide Association Study of PancreatitisR56DK061451 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITCOMB, DAVID CLEMENT · 2011 to 2011
$1.3M
NCBDD CDC HHS R01 DD000295NCI NIH HHS P30 CA047904NCRR NIH HHS UL1 RR024153NIDCR NIH HHS K99 DE025060NIDCR NIH HHS R00 DE025060NIDCR NIH HHS R01 DE011931NIDCR NIH HHS R01 DE014899NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R21 DE016930NIDCR NIH HHS U01 DE020078NIDDK NIH HHS K01 DK120737NIDDK NIH HHS R01 DK061451NIDDK NIH HHS R01 DK077906NIDDK NIH HHS R56 DK061451NIDDK NIH HHS T32 DK063922NIDDK NIH HHS U01 DK108306
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Predisposition to DiseasePancreatitis, ChronicHaplotypesHumansMutationReceptors, Antigen, T-CellTrypsinTrypsinogenPRSS1 protein, humanPRSS2 protein, humanReceptors, Antigen, T-CellTrypsinTrypsinogen

Identifiers

PMID36191639
PMCPMC9892203
OpenAlexW4298111464

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.