ArticleNature communications2022
The mitochondrial calcium uniporter of pulmonary type 2 cells determines severity of acute lung injury.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Small intracellular vesicle-liposome fusogenic nanoplatform sIVs-LPs@Hes: Nebulized delivery targeting pulmonary inflammatory microenvironment to improve ALI.Materials today. Bio · 2026Article
- STUB1-induced polyubiquitination of SIK3 in alveolar type 2 epithelial cells alleviates severity and outcomes of acute lung injury.Cell death & disease · 2026Article
- Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling.Acta pharmaceutica Sinica. B · 2026Article
- Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury.BMJ open respiratory research · 2026Article
- STIM1 as an Early Predictive Biomarker for Acute Respiratory Distress Syndrome (ARDS) and Its Potential Mechanisms.Human mutation · 2026Article
- Macrophage-specific therapy blocks the lung's mechanosensitive immune response to alveolar distension.JCI insight · 2025Article
- Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury.JHEP reports : innovation in hepatology · 2025Article
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- NLRP3 promotes inflammatory signaling and IL-1β cleavage in acute lung injury caused by cell wall extract of Lactobacillus casei.Communications biology · 2025Article
- Mitochondrial Lon Peptidase 1 Controls Diaphragm and Lung Development in a Context-Dependent Manner.Journal of respiratory biology and translational medicine · 2025Article
- Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice.Cell & bioscience · 2024Article
- Macrophage-specific lipid nanoparticle therapy blocks the lung's mechanosensitive immunity due to macrophage-epithelial interactions.bioRxiv : the preprint server for biology · 2024Article
- Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.Cell stem cell · 2024Article
- Pulmonary surfactant and prostaglandin EPhysiological reports · 2024Article
- Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era.Frontiers in microbiology · 2024Review
- The pathogenesis of influenza in intact alveoli: virion endocytosis and its effects on the lung's air-blood barrier.Frontiers in immunology · 2024Review
- Reconstruction of the alveolar-capillary barrier in vitro based on a photo-responsive stretchable Janus membrane.Smart medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Mohammad Naimul IslamDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.ORCID 0000-0001-7929-9444
Galina A GusarovaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Shonit R DasDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Li LiDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Eiji MonmaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Murari AnjaneyuluDepartment of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Liberty MthunziDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.ORCID 0000-0002-4636-4884
Sadiqa K QuadriDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Edward Owusu-AnsahDepartment of Physiology and Cellular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Sunita BhattacharyaDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Jahar BhattacharyaDepartment of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA. jb39@cumc.columbia.edu.ORCID 0000-0002-5588-6211
Columbia University · US
Funding
OPTICAL IMAGING OF MESENCHYMAL STEM CELL INTERACTIONS WITH LUNG MICROVESSELSR01HL057556 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1997 to 2020
$8.0MMICROPUNCTURE STUDIES OF LUNG, WATER AND SOLUTE EXCHANGER01HL036024 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1985 to 2025
$7.0MMICROPUNCTURE STUDIES OF LUNG WATER SOLUTE EXCHANGER37HL036024 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1998 to 2007
$3.0MIdentifying Remote Regulators of Complex I Biogenesis in DrosophilaR35GM124717 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2017 to 2021
$2.2MMitochondrial dynamics in acute lung injuryR01HL122730 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BHATTACHARYA, JAHAR · 2015 to 2018
$1.8MBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kGenetic Dissection of OXPHOS Assembly in Skeletal MusclesR21AR077312 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2020 to 2021
$387kNHLBI NIH HHS R01 HL036024NHLBI NIH HHS R01 HL057556NHLBI NIH HHS R01 HL122730NHLBI NIH HHS R37 HL036024NIAMS NIH HHS R21 AR077312NIGMS NIH HHS R35 GM124717NIH HHS S10 OD020056
Abstract
Acute Lung Injury (ALI) due to inhaled pathogens causes high mortality. Underlying mechanisms are inadequately understood. Here, by optical imaging of live mouse lungs we show that a key mechanism is the viability of cytosolic Ca
Indexed as
Acute Lung InjuryLipopolysaccharidesAnimalsCalciumCalcium ChannelsLungMiceMice, KnockoutSurface-Active AgentsCalciumCalcium ChannelsLipopolysaccharidesmitochondrial calcium uniporterSurface-Active Agents
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.