ArticleeLife2022
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
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- Single-cell aging trajectories reveal a dynamic coupling between nuclear size and proteasome concentration.iScience · 2026Article
- Ribosome Molecular Aging Shapes Translation Dynamics.bioRxiv : the preprint server for biology · 2026Article
- DUX4-induced HSATII RNA accumulation drives protein aggregation, impacting RNA processing pathways.The Journal of cell biology · 2026Article
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis.bioRxiv : the preprint server for biology · 2025Article
- Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan.bioRxiv : the preprint server for biology · 2025Article
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level.bioRxiv : the preprint server for biology · 2025Article
- Artificial chromosome reorganization reveals high plasticity of the budding and fission yeast genomes.Genome biology · 2025Article
- Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders.Frontiers in pharmacology · 2025Review
- iPAR: a new reporter for eukaryotic cytoplasmic protein aggregation.BMC methods · 2025Article
- Reliable replicative lifespan determination of yeast with a single-channel microfluidic chip.Biology open · 2024Article
- Decoding the molecular script of 2'-O-ribomethylation: Implications across CNS disorders.Heliyon · 2024Review
- Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation.Molecular biology of the cell · 2024Article
- Study of impacts of two types of cellular aging on the yeast bud morphogenesis.PLoS computational biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Julie Paxman *Department of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Zhen Zhou *Department of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.ORCID 0000-0003-0706-9089
Richard O'LaughlinDepartment of Bioengineering, University of California, San Diego, La Jolla, United States.
Yuting LiuDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Yang LiDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-5714-0416
Wanying TianDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Hetian SuDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Yanfei JiangDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Shayna E HolnessDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, United States.ORCID 0000-0001-6730-0583
Elizabeth StasiowskiDepartment of Bioengineering, University of California, San Diego, La Jolla, United States.
Lev S TsimringSynthetic Biology Institute, University of California, San Diego, La Jolla, United States.ORCID 0000-0003-0709-3548
Lorraine PillusDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.ORCID 0000-0002-8818-5227
Jeff HastyDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.
Nan HaoDepartment of Molecular Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, United States.ORCID 0000-0003-2857-4789
University of California San Diego · US
Funding
GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8MNetwork-Driven Dynamics of Replicative AgingR01AG056440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEFF M HASTY, Nan Hao · 2017 to 2026
$5.6MTraining in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8MDynamically compartmentalized control of gene expression by messenger ribonucleoprotein granulesR01GM111458 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAO, NAN · 2014 to 2022
$3.4MSystems biology analysis of RNA-binding protein aggregation during cellular agingR01AG068112 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAO, NAN · 2021 to 2025
$2.3MSystems Biology analysis of RNA-binding protein aggregation during cellular agingR56AG068112 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAO, NAN · 2020 to 2020
$394kNIA NIH HHS R01 AG056440NIA NIH HHS R01 AG068112NIA NIH HHS R56 AG068112NIBIB NIH HHS T32 EB009380NIGMS NIH HHS R01 GM111458NIGMS NIH HHS T32 GM007240
Abstract
Chromatin instability and protein homeostasis (proteostasis) stress are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed that, during the replicative aging of
Indexed as
Saccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeChromatinDNA, RibosomalLysineProteostasisRNA-Binding ProteinsRNA, RibosomalSaccharomyces cerevisiaeSirtuin 2ChromatinDNA, RibosomalLysineRNA-Binding ProteinsRNA, RibosomalSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSirtuin 2cell biologychromatin stabilitycomputational biologymicrofluidicsproteostasisS. cerevisiaesingle-cell agingsystems biologytime-lapse imaging
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.