Evidence map›Paper›PMID 36194598›Full record

ArticleCarcinogenesis2022

A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.

Lin Zhao, Jianjun Lei, Shanzhi Gu, Yujiao Zhang, Xin Jing, Lu Wang, Lifen Zhang, Qian Ning, Minna Luo, Yifan Qi and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Lin ZhaoDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.ORCID 0000-0002-2852-8558
Jianjun LeiDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Shanzhi GuDepartment of Forensic Medicine, Xi'an Jiaotong University, Xi'an, 710061, China.
Yujiao ZhangDepartment of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Xin JingDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Lu WangDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Lifen ZhangDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Qian NingDepartment of Respiratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Minna LuoDepartment of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Yifan QiShanghai Crosspoint High School, No.980 Jiangchuan East Road, Minhang District, Shanghai, 200240, China.
Xinhan ZhaoDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Shan ShaoDepartment of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNShanghai Jinyuan Senior High School · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Notch1 (Notch1 receptor) and yes-associated protein 1 (YAP1) signaling can regulate breast cancer metastasis. This study aimed at investigating whether and how these two signal pathways crosstalk to promote breast cancer lung metastasis. Here, we show that YAP1 expression was positively correlated with Notch1 in breast cancer according to bioinformatics and experimental validation. Mechanistically, YAP1 with TEA domain transcription factors (TEADs) enhanced Jagged1(JAG1)-Notch1 signaling. Meanwhile, Notch1 promoted YAP1 stability in breast cancer cells by inhibiting the β-TrCP-mediated degradation, thereby, forming a YAP1- JAG1/Notch1 positive feedback loop in breast cancer. Furthermore, YAP1 enhanced the mammosphere formation and stemness of MDA-MB-231 cells by attenuating the inhibition of the BMP4-SMAD1/5 signaling. In vivo, the YAP1- JAG1/Notch1 positive feedback loop promoted the lung colonization of MDA-MB-231 cells. Our data for the first time indicate that the YAP1-Notch1 positive feedback loop promotes lung metastasis of breast cancer by modulating self-renewal and inhibiting the BMP4-SMAD1/5 signaling.

Indexed as

Breast NeoplasmsLung NeoplasmsAdaptor Proteins, Signal TransducingBone Morphogenetic Protein 4Cell Line, TumorFamilyFeedbackFemaleHumansReceptor, Notch1Signal TransductionTranscription FactorsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingBone Morphogenetic Protein 4NOTCH1 protein, humanReceptor, Notch1Transcription FactorsYAP-Signaling Proteins

Identifiers

PMID36194598
PMCPMC10122426
OpenAlexW4301181123

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.