Evidence map›Paper›PMID 36195072›Full record

ReviewNephron2023

Intestinal Microbiota in Experimental Acute Kidney Injury.

Neal Shah, Hamid Rabb

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nephron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. ProbioticJournal of biomedical research · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Neal ShahDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA, nshah74@jhmi.edu.
Hamid RabbDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Acute Kidney Injury and Double Negative T CellsR01DK104662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HAMAD, ABDEL RAHIM, RABB, HAMID · 2015 to 2023
$3.8M
Acute kidney injury and microbiomeR01DK123342 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RABB, HAMID · 2020 to 2024
$3.0M
NIDDK NIH HHS R01 DK104662NIDDK NIH HHS R01 DK123342
6 · The paper itself

Abstract

Recent studies have demonstrated an important role played by gut microbiota in maintaining intestinal homeostasis and host immune system function. Gut microbiota have been studied in experimental acute kidney injury (AKI) using different mice and rat models exposed to either ischemia or cisplatin-mediated tubular injury. Differences in inflammatory markers and severity of AKI have been observed between germ-free mice, wild-type mice, and mice treated with antibiotics or specific bacteria. Interventions modifying the gut microbiota after experimental AKI have had either beneficial or harmful effects on kidney tubular injury and recovery. These findings provide strong evidence for a modulatory role of gut microbiota during AKI. Ischemic and cis-platin-induced AKI have distinct stool microbial signatures based on 16s sequencing. Future in-depth studies exploring the mechanisms of how the microbiota influence AKI and development of feasible therapeutic options have the potential to improve outcomes in clinical AKI.

Indexed as

Acute Kidney InjuryGastrointestinal MicrobiomeMicrobiotaReperfusion InjuryAnimalsIschemiaKidneyMiceRatsAcute kidney injuryGut microbiotaInflammationIschemic-reperfusion injury

Identifiers

PMID36195072
PMCPMC9928605
OpenAlexW4301187576

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.