ArticleDevelopment (Cambridge, England)2022
Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos.
Article in Development (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- The choreography of development: RNA localization across time and space.Development (Cambridge, England) · 2026Review
- GLA-3 mediates the heat shock response in Caenorhabditis elegans germ cells: A key role for the tristetraprolin (TTP) family.PloS one · 2026Article
- Regulation of Xvelo assembly by centrosomal proteins.iScience · 2025Article
- Remodeling of Germ Cell mRNPs for Translational Control.Biology · 2025Review
- Stress-Induced Membraneless Organelles in Neurons: Bridging Liquid-Liquid Phase Separation and Neurodevelopmental Dysfunction.International journal of molecular sciences · 2025Review
- From embryos to condensates: A developmental biologist's journey.Journal of molecular biology · 2025Article
- Why has the 'miracidium' of Notocotylidae (Trematoda: Digenea) lost all stage-specific traits?Parasitology research · 2025Article
- Piwi mutant germ cells transmit a form of heritable stress that promotes longevity.Aging cell · 2025Article
- How germ granules promote germ cell fate.Nature reviews. Genetics · 2024Review
- Spatial organization of translation and translational repression in two phases of germ granules.Nature communications · 2024Article
- Exploring the Role of the Processing Body in Plant Abiotic Stress Response.Current issues in molecular biology · 2024Review
- Caenorhabditis elegans germ granules accumulate hundreds of low translation mRNAs with no systematic preference for germ cell fate regulators.Development (Cambridge, England) · 2024Article
- P-body-like condensates in the germline.Seminars in cell & developmental biology · 2024Review
- Organogenetic transcriptomes of the Drosophila embryo at single cell resolution.Development (Cambridge, England) · 2024Article
- Condensate cooperativity underlies transgenerational gene silencing.Cell reports · 2023Article
- RNA granules: functional compartments or incidental condensates?Genes & development · 2023Review
- Plasticity of Drosophila germ granules during germ cell development.PLoS biology · 2023Article
- Germ granules in development.Development (Cambridge, England) · 2023Article
- Structural and functional organization of germ plasm condensates.The Biochemical journal · 2022Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In animals with germ plasm, specification of the germline involves 'germ granules', cytoplasmic condensates that enrich maternal transcripts in the germline founder cells. In Caenorhabditis elegans embryos, P granules enrich maternal transcripts, but surprisingly P granules are not essential for germ cell fate specification. Here, we describe a second condensate in the C. elegans germ plasm. Like canonical P-bodies found in somatic cells, 'germline P-bodies' contain regulators of mRNA decapping and deadenylation and, in addition, the intrinsically-disordered proteins MEG-1 and MEG-2 and the TIS11-family RNA-binding protein POS-1. Embryos lacking meg-1 and meg-2 do not stabilize P-body components, misregulate POS-1 targets, mis-specify the germline founder cell and do not develop a germline. Our findings suggest that specification of the germ line involves at least two distinct condensates that independently enrich and regulate maternal mRNAs in the germline founder cells. This article has an associated 'The people behind the papers' interview.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.