ArticleCerebral cortex (New York, N.Y. : 1991)2023
Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Age-related constraints on the spatial geometry of the brain.Nature communications · 2025Article
- No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts.Scientific reports · 2025Article
- Age-related disturbances in rest-activity rhythms and integrity of the hippocampal network: An exploratory study.Neurobiology of sleep and circadian rhythms · 2025Article
- Extreme signal amplitude events in neuromagnetic oscillations reveal brain aging processing across adulthood.Frontiers in aging neuroscience · 2025Article
- Population clustering of structural brain aging and its association with brain development.eLife · 2024Article
- Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.Age and ageing · 2024Article
- Population clustering of structural brain aging and its association with brain development.medRxiv : the preprint server for health sciences · 2024Article
- A Subtype Perspective on Cognitive Trajectories in Healthy Aging.Brain sciences · 2024Article
- Grey-matter structure in cortical and limbic regions correlates with general cognitive ability in old age.Aging brain · 2024Article
- Aging Brain from a Lifespan Perspective.Current topics in behavioral neurosciences · 2024Review
- The theory of orchid and dandelion offers a new subtyping framework for cognitive aging.Aging · 2023Article
- Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Longitudinal change-change associations of cognition with cortical thickness and surface area.Aging brain · 2023Article
- Conceptualizing healthy cognitive aging: the role of time and variability.Frontiers in human neuroscience · 2023Article
Corrections and comments
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Authors and funding
29 authors at 14 institutions in 9 countries.
Funding
Abstract
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.