ArticleScience translational medicine2022
Assessment of cholesterol homeostasis in the living human brain.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics.Neuropharmacology · 2026Article
- Head-to-head comparison of [European journal of nuclear medicine and molecular imaging · 2026Article
- CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- DHCR24 in cholesterol metabolism and diseases of the nervous system.Lipids in health and disease · 2026Review
- Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preclinical development of [European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Radiosynthesis and Evaluation ofACS medicinal chemistry letters · 2026Article
- Quantitative analysis of [European journal of nuclear medicine and molecular imaging · 2026Article
- Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- ABC Transporters, APOE, CYP46A1, and LRP1 Gene Polymorphisms as Markers of Dementia Development in Patients with Hyperlipidemia.International journal of molecular sciences · 2025Article
- Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2025Article
- Brain Cytochrome P450: Navigating Neurological Health and Metabolic Regulation.Journal of xenobiotics · 2025Review
- Development of a NovelACS pharmacology & translational science · 2025Article
- Brain cholesterol therapy for Huntington's disease - Does it make sense?Clinical and translational medicine · 2024Article
- Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [EJNMMI radiopharmacy and chemistry · 2024Article
- Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders.Molecular neurobiology · 2024Review
- Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development.Brain : a journal of neurology · 2024Review
- Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer's astrocytes.Alzheimer's research & therapy · 2024Review
- CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.Science advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 11 institutions in 6 countries.
Achi HaiderDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0002-5204-4473
Chunyu ZhaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0003-0168-2130
Lu WangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.ORCID 0000-0002-8049-1991
Zhiwei XiaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Jian RongDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Xiaotian XiaDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0002-3917-4361
Zhen ChenDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0002-6289-4332
Stefanie K PfisterDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0002-1394-3716
Natalia MastDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-6427-640X
Eylan YutucInstitute of Life Science, Swansea University Medical School, SA2 8PP Swansea, Wales, UK.ORCID 0000-0001-9971-1950
Jiahui ChenDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0001-9186-1110
Yinlong LiDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0002-8864-1712
Tuo ShaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Geoffrey I WarnockDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Alyaa DawoudBiochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835 Cairo, Egypt.ORCID 0000-0002-8140-1070
Theresa R ConnorsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9706-8217
Derek H OakleyHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-6998-9510
Huiyi WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Jinghao WangDepartment of Pharmacy, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Zhihua ZhengGuangdong Province Pharmaceutical Association, Guangzhou 510080, China.ORCID 0000-0001-9312-5846
Hao XuCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
April T DavenportDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
James B DaunaisDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
Richard S VanDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Yihan ShaoDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Yuqin WangInstitute of Life Science, Swansea University Medical School, SA2 8PP Swansea, Wales, UK.ORCID 0000-0002-3063-3066
Ming-Rong ZhangDepartment of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Catherine GebhardDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7240-5822
Irina PikulevaDepartment of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-9742-6232
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-3153-502X
William J GriffithsInstitute of Life Science, Swansea University Medical School, SA2 8PP Swansea, Wales, UK.ORCID 0000-0002-4129-6616
Steven H LiangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0003-1413-6315
Emory Healthcare · USHarvard University · USFirst Affiliated Hospital of Jinan University · CNSwansea University · GBCase Western Reserve University · USUniversity of Oklahoma · USUniversity of Zurich · CHWake Forest University · USEmory University · USGerman University in Cairo · EGNational Institutes for Quantum Science and Technology · JP
Funding
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5MSupplement for Ligand discovery for delineating cholesterol homeostasis in the brainR01AG070060 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2021 to 2025
$4.2MCholesterol Metabolizing P450s: Structure and FunctionR01AG067552 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI PIKULEVA, IRINA A · 2020 to 2024
$2.2MPET Imaging for neuroinflammation in Alzheimer's diseaseR21AG074218 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2021 to 2022
$442kAdvancing Neuroimaging in Nonhuman PrimatesR21AA028007 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAUNAIS, JAMES B · 2020 to 2021
$396kBiotechnology and Biological Sciences Research Council BB/L001942/1Biotechnology and Biological Sciences Research Council BB/N015932/1Biotechnology and Biological Sciences Research Council BB/S019588/1NIAAA NIH HHS R21 AA028007NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG067552NIA NIH HHS R01 AG070060NIA NIH HHS R21 AG074218
Abstract
Alterations in brain cholesterol homeostasis have been broadly implicated in neurological disorders. Notwithstanding the complexity by which cholesterol biology is governed in the mammalian brain, excess neuronal cholesterol is primarily eliminated by metabolic clearance via cytochrome P450 46A1 (CYP46A1). No methods are currently available for visualizing cholesterol metabolism in the living human brain; therefore, a noninvasive technology that quantitatively measures the extent of brain cholesterol metabolism via CYP46A1 could broadly affect disease diagnosis and treatment options using targeted therapies. Here, we describe the development and testing of a CYP46A1-targeted positron emission tomography (PET) tracer,
Indexed as
Alzheimer DiseaseBrainAnimalsCholesterolCholesterol 24-HydroxylaseFemaleHomeostasisHumansMaleMammalsMiceCholesterolCholesterol 24-Hydroxylase
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.