ArticleScience translational medicine2022
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- GnRH-receptor antagonism as a targeted approach to reproductive dysfunction in polycystic ovary syndrome.EBioMedicine · 2026Article
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Preoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.Nature communications · 2026Article
- Effects of Nitric Oxide Expression on Hearing Loss.International journal of molecular sciences · 2025Review
- Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells.Nature communications · 2025Article
- GnRH and Cognition.Endocrinology · 2025Review
- Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility.Theranostics · 2025Article
- The ventral premammillary nucleus at the interface of environmental cues and social behaviors.Frontiers in neuroscience · 2025Review
- Disorders of puberty and neurodevelopment: A shared etiology?Annals of the New York Academy of Sciences · 2024Review
- A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice.Nature neuroscience · 2024Article
- Article
- Stress during pubertal development affects female sociosexual behavior in mice.Nature communications · 2024Article
- A role for nNOS in mediating stress and female sexual behavior in mice.Nature communications · 2024Article
- Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits.Nature reviews. Endocrinology · 2024Article
- Illuminating the terminal nerve: Uncovering the link between GnRH-1 neuron and olfactory development.The Journal of comparative neurology · 2024Article
- Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work.Nature reviews. Endocrinology · 2024Review
- Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback.Peptides · 2023Review
- Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 17 institutions in 9 countries.
Konstantina ChachlakiUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0002-7496-3526
Andrea MessinaService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0002-2393-1874
Virginia DelliUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0001-9137-8735
Valerie LeysenUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.
Csilla MaurnyiLaboratory of Reproductive Neurobiology, Institute of Experimental Medicine, 43 Szigony St., Budapest 1083, Hungary.
Chieko HuberDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, Geneva 1211, Switzerland.ORCID 0000-0003-0847-0181
Gaëtan TernierUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0002-0004-1457
Katalin SkrapitsLaboratory of Reproductive Neurobiology, Institute of Experimental Medicine, 43 Szigony St., Budapest 1083, Hungary.
Georgios PapadakisService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0002-0099-6755
Sonal ShrutiUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0003-3772-1939
Maria KapanidouDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
Xu ChengService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0002-2488-4424
James AciernoService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.
Jesse RademakerService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0003-3961-3333
Sowmyalakshmi RasikaUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0001-8733-4641
Richard QuintonTranslational and Clinical Research Institute and the Royal Victoria Infirmary, University of Newcastle , Tyne NE1 3BZ, UK.ORCID 0000-0002-4842-8095
Marek NiedzielaDepartment of Paediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan 61-701, Poland.ORCID 0000-0001-8862-6937
Dagmar L'AllemandDepartment of Endocrinology, Children's Hospital of Eastern Switzerland, St. Gallen 9000, Switzerland.ORCID 0000-0003-3144-3907
Duarte PignatelliDepartment of Endocrinology, Hospital S João; Department of Biomedicine, Faculty of Medicine of the University of Porto; IPATIMUP Research Institute, Porto 4200-319, Portugal.ORCID 0000-0002-5555-7004
Mirjam DirlewanderPediatric Endocrine and Diabetes Unit, Children's Hospital, University Hospitals and Faculty of Medicine, Geneva CH1205, Switzerland.
Mariarosaria Lang-MuritanoDivision of Pediatric Endocrinology and Diabetology and Children's Research Centre, University Children's Hospital, Zürich 8032, Switzerland.
Patrick KempfDepartment of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.
Sophie Catteau-JonardUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0003-1285-6423
Nicolas J NiederländerService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.
Philippe CiofiInserm, U1215, Neurocentre Magendie, Université de Bordeaux, Bordeaux F-33077, France.
Manuel Tena-SempereDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba 14004, Spain.ORCID 0000-0002-4741-5567
John GarthwaiteWolfson Institute for Biomedical Research, University College London, London WC1E 6DH, UK.ORCID 0000-0003-1970-8095
Laurent StormeFHU 1000 Days for Health, School of Medicine, Lille F-59000, France.
Paul AvanUniversité de Clerremont-Ferrand, Clermont-Ferrand F-63000, France.ORCID 0000-0003-1054-1479
Erik HrabovszkyLaboratory of Reproductive Neurobiology, Institute of Experimental Medicine, 43 Szigony St., Budapest 1083, Hungary.ORCID 0000-0001-6927-0015
Alan CarletonDepartment of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, Geneva 1211, Switzerland.ORCID 0000-0001-5633-9159
Federico SantoniService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0002-3258-4747
Paolo GiacobiniUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0002-3075-1441
Nelly PitteloudService of Endocrinology, Diabetology, and Metabolism, Lausanne University Hospital, Lausanne 1011, Switzerland.ORCID 0000-0003-0971-3237
Vincent PrevotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR-S 1172, Lille F-59000, France.ORCID 0000-0001-7185-3615
Inserm · FRUniversity of Lausanne · CHHUN-REN Institute of Experimental Medicine · HUUniversity of Geneva · CHHospital de São João · PTInstituto de Salud Carlos III · ESOstschweizer Kinderspital · CHOxford Brookes University · GBPoznan University of Medical Sciences · PLRoyal Victoria Infirmary · GBUniversité de Bordeaux · FRUniversité de Lille · FRUniversity Children's Hospital Zurich · CHUniversity Hospital of Bern · CHUniversity Hospital of Geneva · CHUniversity of Clermont Auvergne · FRWolfson Foundation · GB
Funding
Swiss National Science Foundation 173260
Abstract
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase (NOS1) activity underlies some forms of hypogonadotropic hypogonadism. Whole-exome sequencing was performed on a cohort of 341 probands with congenital hypogonadotropic hypogonadism to identify ultrarare variants in
Indexed as
HypogonadismNitric OxideAnimalsCognitionGonadotropin-Releasing HormoneHumansMiceMutant ProteinsMutationNitric Oxide Synthase Type INitritesGonadotropin-Releasing HormoneMutant ProteinsNitric OxideNitric Oxide Synthase Type INitritesNOS1 protein, humanNos1 protein, mouse
Identifiers
What Socratic holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.