Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model.

Tsukasa Takahashi, Yuki Takahashi, Erin L Fee, Haruo Usuda, Lucy Furfaro, John P Newnham, Alan H Jobe, Matthew W Kemp

Abstract read

In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model.Physiological reports · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tsukasa TakahashiDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-5567-4091

Yuki TakahashiDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Erin L FeeDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Haruo UsudaDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Lucy FurfaroDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

John P NewnhamDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Alan H JobeDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Matthew W KempDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment with antenatal steroids (ANS) is standard practice for reducing the risk of respiratory distress in the preterm infant. Despite clear overall benefits when appropriately administered, many fetuses fail to derive benefit from ANS therapies. In standardized experiments using a pregnant sheep model, we have demonstrated that around 40% of ANS-exposed lambs did not have functional lung maturation significantly different from that of saline-treated controls. Surfactant protein A is known to play an important role in lung function. In this genotyping study, we investigated the potential correlation between polymorphisms in SFTPA1, messenger RNA and protein levels, and ventilation outcomes in animals treated with ANS. 45 preterm lambs were delivered 48 h after initial ANS therapy and 44 lambs were delivered 8 days after initial ANS therapy. The lambs were ventilated for 30 min after delivery. SFTPA1 mRNA expression in lung tissue was not correlated with arterial blood PaCO

Indexed as

Polymorphism, Single NucleotidePulmonary Surfactant-Associated Protein AAnimalsAnimals, NewbornFemaleHumansInfant, NewbornInfant, PrematureLungPregnancyRNA, MessengerSheepSteroidsSurface-Active AgentsPulmonary Surfactant-Associated Protein ARNA, MessengerSteroidsSurface-Active Agentsantenatal corticosteroidslung maturationpreterm birthsheepsingle nucleotide polymorphisms

Identifiers

PMID36200269

DOI10.14814/phy2.15477

PMCPMC9535346

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.