Evidence map›Paper›PMID 36200761›Full record

ArticleAntimicrobial agents and chemotherapy2022

Exploring Cluster-Dependent Antibacterial Activities and Resistance Pathways of NOSO-502 and Colistin against Enterobacter cloacae Complex Species.

Lucile Pantel, François Guérin, Marine Serri, François Gravey, Jessica Houard, Kelly Maurent, Marie Attwood, Alan Noel, Alasdair MacGowan, Emilie Racine and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Colistin heteroresistance inAntimicrobial agents and chemotherapy · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Design and Synthesis of Novel Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Lucile PantelNosopharm, Nîmes, France.
François GuérinCHU de Rennes, Service de Bactériologie-Hygiène Hospitalière, Rennes, France.
Marine SerriNosopharm, Nîmes, France.
François GraveyUniversité de Caen Normandie, Dynamicure, INSERM U1311, CHU de Caen, Caen, France.ORCID 0000-0001-8672-8286
Jessica HouardNosopharm, Nîmes, France.
Kelly MaurentNosopharm, Nîmes, France.
Marie AttwoodBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.
Alan NoelBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.
Alasdair MacGowanBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.
Emilie RacineNosopharm, Nîmes, France.
Vincent CattoirCHU de Rennes, Service de Bactériologie-Hygiène Hospitalière, Rennes, France.ORCID 0000-0003-4026-9912
Maxime GualtieriNosopharm, Nîmes, France.ORCID 0000-0001-6590-2468
Inserm · FRSouthmead Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Enterobacter cloacae complex (ECC) is a group of diverse environmental and clinically relevant bacterial species associated with a variety of infections in humans. ECC have emerged as one of the leading causes of nosocomial infections worldwide. The purpose of this paper is to evaluate the activity of NOSO-502 and colistin (CST) against a panel of ECC clinical isolates, including different Hoffmann's clusters strains, and to investigate the associated resistance mechanisms. NOSO-502 is the first preclinical candidate of a novel antibiotic class, the odilorhabdins (ODLs). MIC

Indexed as

ColistinEnterobacter cloacaeAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, BacterialHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsColistincolistinCrrAB two-component-systemEnterobacter cloacae complexhetero-resistanceKexD efflux pumpmechanism of resistanceNOSO-502PhoPQ

Identifiers

PMID36200761
PMCPMC9664853
OpenAlexW4302761426

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.