ArticleNature communications2022
Endothelial cell cycle state determines propensity for arterial-venous fate.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
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Who cites it
55 citing papers in PubMed, 74 citations in OpenAlex.
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- Gene-Specific Endothelial Programs Drive AVM Pathogenesis inArteriosclerosis, thrombosis, and vascular biology · 2026Article
- Regulation of endothelial cell chromatin availability and transcription factor activity during arterial-venous specification.Development (Cambridge, England) · 2026Article
- A Perturb-seq screen guided by species divergence uncovers pathways for collateral artery formation.bioRxiv : the preprint server for biology · 2026Article
- Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis.iScience · 2026Article
- Feeder-Free Generation of Lymphatic Endothelial Cells from Human Induced Pluripotent Stem Cells.bioRxiv : the preprint server for biology · 2026Article
- An atlas of cGAS-STING signaling in pathophysiological angiogenesis and retinal vascular homeostasis across species.Molecular therapy. Nucleic acids · 2026Article
- Diverse roles of connexins in the neuro-vasculature in homeostasis and disease.Translational neuroscience · 2026Review
- Flow-induced Klf4-Akt signaling links EC cycling to mural cell defects in arterial-venous malformations.Theranostics · 2026Article
- Arterial iron regulates vasodilation during anemia via endothelial holo-alpha globin.bioRxiv : the preprint server for biology · 2025Article
- Pharmacological activation of p53 induces dose-dependent changes in endothelial cell fate during angiogenic sprouting.Cell death & disease · 2025Article
- Executive summary of the 15th HHT international scientific conference.Angiogenesis · 2025Article
- Emergence of endothelial subtypes and role of cell cycle control in arterial-venous specification during embryonic vascular development.Cell reports · 2025Article
- Zonal endothelial cell heterogeneity underlies murine renal vascular development.Angiogenesis · 2025Article
- Article
- Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells.Nature communications · 2025Article
- Impact of Poly(Lactic Acid) and Graphene Oxide Nanocomposite on Cellular Viability and Proliferation.Pharmaceutics · 2025Article
- Aged human serum induces vascular changes in an isogenic co-culture venule model.Stem cell reports · 2025Article
- Microenvironmental determinants of endothelial cell heterogeneity.Nature reviews. Molecular cell biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Nicholas W ChavkinDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0001-9058-0245
Gael GenetDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0003-0016-5887
Mathilde PouletDepartment of Medicine, Yale Cardiovascular Research Center Yale University School of Medicine, New Haven, CT, 06520, USA.ORCID 0000-0002-2216-4132
Erin D JefferyDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0001-9511-7719
Corina MarzianoDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Nafiisha GenetDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Hema VasavadaDepartment of Medicine, Yale Cardiovascular Research Center Yale University School of Medicine, New Haven, CT, 06520, USA.
Elizabeth A NelsonDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Bipul R AcharyaDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Anupreet KourRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Jordon AragonDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0003-0997-5819
Stephanie P McDonnellDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Mahalia HubaDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Gloria M SheynkmanDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0002-4223-9947
Kenneth WalshRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID 0000-0001-7580-2276
Karen K HirschiDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. kkh4yy@virginia.edu.ORCID 0000-0001-7116-0130
University of Virginia · USYale University · US
Funding
Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1MBASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MMultidisciplinary Training in Cardiovascular ResearchT32HL007224 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM, WAINFORD, RICHARD DAVID · 1985 to 2020
$12.3MMulti-tissue platform for modeling systemic pathologiesUH3EB025765 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VUNJAK-NOVAKOVIC, GORDANA · 2019 to 2021
$4.0MWnt signaling control of vascular phenotype in obesityR01HL142650 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2019 to 2023
$3.1MDefining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0MEndothelial Cell Cycle State and Cell FateR01HL146056 · NHLBI · UNIVERSITY OF VIRGINIA · PI HIRSCHI, KAREN KEMPER · 2019 to 2022
$2.1MHematopoietic stem cell mutations and ischemic cardio-metabolic diseaseR01HL141256 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2019 to 2022
$1.9MIntegrated heart-liver-vascular systems for drug testing in human health and diseUH2EB017103 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2012 to 2013
$1.7MNCI NIH HHS P30 CA044579NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141256NHLBI NIH HHS R01 HL142650NHLBI NIH HHS R01 HL146056NHLBI NIH HHS T32 HL007224NHLBI NIH HHS T32 HL007284NIBIB NIH HHS UH2 EB017103NIBIB NIH HHS UH3 EB025765
Abstract
During blood vessel development, endothelial cells become specified toward arterial or venous fates to generate a circulatory network that provides nutrients and oxygen to, and removes metabolic waste from, all tissues. Arterial-venous specification occurs in conjunction with suppression of endothelial cell cycle progression; however, the mechanistic role of cell cycle state is unknown. Herein, using Cdh5-CreER
Indexed as
Endothelial CellsTransforming Growth Factor beta1AnimalsArteriesCell CycleMiceOxygenVeinsOxygenTransforming Growth Factor beta1
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.