Evidence map›Paper›PMID 36203577›Full record

ArticleFrontiers in immunology2022

Optic nerve head: A gatekeeper for vitreous infectious insults?

Wenwen Lai, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Xiaowei Wang, Fengfei Ding

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Wenwen LaiDepartment of Pharmacology, School of Basic Medical Sciences; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Fudan University, Shanghai, China.
Jie HuangDepartment of Pharmacology, School of Basic Medical Sciences; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Fudan University, Shanghai, China.
Wangyi FangDepartment of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Saiyue DengDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi XieDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wei WangDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tong QiaoDepartment of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Gezhi XuDepartment of Pharmacology, School of Basic Medical Sciences; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Fudan University, Shanghai, China.
Xiaowei WangDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA, United States.
Fengfei DingDepartment of Pharmacology, School of Basic Medical Sciences; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Fudan University, Shanghai, China.
Huazhong University of Science and Technology · CNFudan University · CNScience and Technology Commission of Shanghai Municipality · CNShanghai Children's Hospital · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CNTongji Hospital · CNUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The axons of retinal ganglion cells (RGCs) pass through the optic nerve head (ONH) and form the optic nerve (ON). The ONH serves as an anatomical interface between the vitreous cavity and subarachnoid space. After inducing acute neuroinflammation by intravitreal injection of lipopolysaccharides (LPS), we observed inflammatory activation in the retina, but detect no signs of inflammation in the posterior ON or infiltration of inflammatory cells in the ONH. Therefore, we hypothesized that the ONH functions as a barrier to vitreous inflammation. Using transmission electron microscopy, we identified significant increase in G-ratio in the posterior ON on day 7 post intravitreal injection (PII) of LPS compared with the phosphate buffered saline (PBS) group. Moreover, using confocal imaging of

Indexed as

Optic DiskAnimalsInflammationLipopolysaccharidesMicePhosphatesRatsRetinal Ganglion CellsLipopolysaccharidesPhosphatesastrocytedemyelinationglial lamina cribrosalipopolysaccharidesneuroinflammationoptic nerve head

Identifiers

PMID36203577
PMCPMC9531234
OpenAlexW4296401062

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.