Evidence map›Paper›PMID 36208323›Full record

ArticlePediatric surgery international2022

Age disparities in intestinal stem cell quantities: a possible explanation for preterm infant susceptibility to necrotizing enterocolitis.

Brian D Hosfield, W Christopher Shelley, Fikir M Mesfin, John P Brokaw, Krishna Manohar, Jianyun Liu, Hongge Li, Anthony R Pecoraro, Kanhaiya Singh, Troy A Markel

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Brian D Hosfield *Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
W Christopher Shelley *Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Fikir M MesfinDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
John P BrokawDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Krishna ManoharDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Jianyun LiuDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Hongge LiDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Anthony R PecoraroDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Kanhaiya SinghIndiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN, USA.
Troy A MarkelDepartment of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. tmarkel@iupui.edu.ORCID http://orcid.org/0000-0002-6429-2976
Indiana University School of MedicineIndiana University Health · US

Funding

Mesenchymal Stromal Cells Modulate Intestinal Mesenteric Endothelium Via Hydrogen SulfideK08DK113226 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MARKEL, TROY A · 2018 to 2021
$603k
NIDDK NIH HHS K08 DK113226NIDDK NIH HHS K08DK113226
6 · The paper itself

Abstract

purposePreterm infants are more susceptible to necrotizing enterocolitis (NEC) than term Queryinfants. This may be due to a relative paucity of Lgr5

methodsTransgenic mice with EGFP-labeled Lgr5 underwent euthanasia at 10 different time points from E15 to P56 (n = 8-11/group). Lgr5

resultsLgr5

conclusionLgr5

Indexed as

Enterocolitis, NecrotizingInfant, Newborn, DiseasesAnimalsHumansInfant, NewbornInfant, PrematureIntestinal MucosaIntestinesMiceMice, TransgenicStem CellsAnimal studyBmi1Intestinal stem cellsLgr5Necrotizing enterocolitis

Identifiers

PMID36208323
OpenAlexW4303645027

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.