Evidence map›Paper›PMID 36211528›Full record

ArticleFrontiers in nutrition2022

Ferulic acid attenuates high-fat diet-induced hypercholesterolemia by activating classic bile acid synthesis pathway.

Zhixin Luo, Mengqian Li, Jiachuan Yang, Jia Li, Yao Zhang, Fang Liu, Emad El-Omar, Lin Han, Ji Bian, Lan Gong and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zhixin LuoCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Mengqian LiCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Jiachuan YangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Jia LiCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yao ZhangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Fang LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Emad El-OmarMicrobiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia.
Lin HanCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Ji BianKolling Institute, Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Royal North Shore Hospital, St Leonards, NSW, Australia.
Lan GongMicrobiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia.
Min WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, China.
Northwest A&F University · CNSutherland Hospital · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, displays promising therapeutic effects on hypercholesterolemia while its underlying mechanism not fully elucidated. This study aimed to investigate the cholesterol-lowering effect of FA in high-fat diet (HFD)-fed mice and its potential molecular mechanism. FA supplementation alleviated HFD-induced hypercholesterolemia (-13.2%,

Indexed as

bile acidcholesterolCYP7A1ferulic acidhypercholesterolemia

Identifiers

PMID36211528
PMCPMC9536491
OpenAlexW4296994440

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.