Evidence map›Paper›PMID 36211543›Full record

ArticleFrontiers in cardiovascular medicine2022

New adverse coronary events in valve-in-valve TAVR and native TAVR-A 2-year matched cohort.

Ofir Koren, Vivek Patel, Robert Naami, Edmund Naami, Takashi Nagasaka, Alon Shechter, Sharon Shalom Natanzon, Siamak Kohan, Zev Allison, Addee Lerner and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07751965 (Prospective, Multicenter, Single-arm, Open-label Study Evaluating the Safety and Effectiveness of the Myval Transcatheter Heart Valve), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07751965 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective, Multicenter, Single-arm, Open-label Study Evaluating the Safety and Effectiveness of the Myval Transcatheter Heart Valve (THV) System in High-risk Patients With Severe Symptomatic Non- or Mildly Calcified Aortic Regurgitation.

TypeinterventionalSponsorCeric SàrlRan2026 to 2032Enrolled164ConditionsAortic Regurgitation, Aortic Disease, Calcified Aortic ValveArmsMyval THV series
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Ofir KorenCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Vivek PatelCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Robert NaamiInternal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Edmund NaamiSchool of Medicine, University of Illinois, Chicago, IL, United States.
Takashi NagasakaCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Alon ShechterCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Sharon Shalom NatanzonCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Siamak KohanInternal Medicine, Kaiser Permanente Medical Center, Los Angeles, CA, United States.
Zev AllisonCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Addee LernerDavid Geffen School of Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, United States.
Daniel Eugene ChengCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Tarun ChakravartyCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Mamoo NakamuraCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Wen ChengCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Hasan JilaihawiHeart Valve Center, NYU Langone Health, New York, NY, United States.
Raj R MakkarCedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, CA, United States.
Cedars-Sinai Smidt Heart Institute · USCedars-Sinai Medical Center · USCase Western Reserve University · USKaiser Permanente · USUniversity of California, Los Angeles · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the incidence of new adverse coronary events (NACE) following transcatheter aortic valve replacement (TAVR) and valve-in-valve TAVR (ViV-TAVR). Background: ViV-TAVR is an accepted treatment for degenerative prostheses among patients with high surgical-risk. TAVR studies have suggested an increased risk of coronary artery obstruction and flow stasis causing thrombus formation. Whether contemporary ViV-TAVR is associated with higher rate of coronary events compared to TAVR is unknown. Methods: We used data from 1,224 TAVR patients between 2016 and 2021. We propensity-matched patients following ViV-TAVR and TAVR by significant predictors to overcome confounders in patients' baseline characteristics and procedural factors. Results: The matched population included 129 patients in each group. In line with prior reports, there was a higher in-hospital coronary artery obstruction rate with ViV-TAVR (3.1 vs. 1.6%; Conclusion: At 2-year follow-up, ViV-TAVR was not associated with a higher rate of myocardial infarction, unplanned catheterization, coronary artery bypass grafting, or hypoattenuated leaflet thickening.

Indexed as

coronary artery bypass graft (CABG)coronary artery calcium scorecoronary catheterizationlong-term outcome assessmentmyocardial infarctionpropensity score matching (PSM)transcatheter aortic valve replacementvalve-in-valve

Identifiers

PMID36211543
PMCPMC9532571
OpenAlexW4296545264

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.