ReviewTremor and other hyperkinetic movements (New York, N.Y.)2022
Tremor in Parkinson's Disease: From Pathophysiology to Advanced Therapies.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06885541 (Detection of Internal Tremors by Oscillometry in Parkinson's Patient), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of Internal Tremors by Oscillometry in Parkinson's Patient : a Pilot Study
Who cites it
40 citing papers in PubMed, 80 citations in OpenAlex.
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- Flexible and Self-Powered Wearable Sensors for Tremor Monitoring in Parkinson'S Disease: Recent Advances in Materials and Device Architectures.Advanced healthcare materials · 2026Review
- Using Multinodal Deep Brain Stimulation for Treatment of Complex Movement Disorders: Initial Case Series.Operative neurosurgery (Hagerstown, Md.) · 2026Article
- Outcomes of Bilateral Deep Brain Stimulation After Magnetic Resonance‑Guided Focused Ultrasound Thalamotomy: A Case Series.Neurosurgery practice · 2026Article
- Mapping of motor and non-motor symptoms to 12-region dopamine transporter single-photon emission computed tomography in Parkinson's disease.Journal of neurology · 2026Article
- Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson's Disease.Cellular and molecular neurobiology · 2026Review
- The impact of depressive symptoms on 5-year all-cause mortality in patients with parkinson's disease treated with and without deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Dual-target magnetic resonance-guided focused ultrasound of the subthalamic and ventral intermediate nuclei for Parkinson's disease: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Parkinson's Disease: From Metabolism to Genetics-A Comprehensive Review.Current issues in molecular biology · 2026Review
- AI-Enabled Wearables for Motor Function Assessment and Rehabilitation in Parkinson Disease: Scoping Review.Journal of medical Internet research · 2026Review
- Scoping review of AI-driven wearable technologies for rehabilitation and functional assessment in Parkinson's disease: a protocol.BMJ open · 2026Article
- Levodopa exacerbated tremor in Parkinson's disease.Frontiers in neurology · 2026Article
- The Impact of Dance-Based Physical Activity on Sensorimotor and Psychological Function in Parkinson's Disease: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- A Real-World Study on Unstable Parkinson's Disease: Levodopa Dosage Management and the Role of Nonmotor Symptoms.Movement disorders clinical practice · 2025Article
- Added value of a wrist-worn device for assessing tremor in Parkinson's disease: reliability and validity of tremor evaluation at home.NPJ Parkinson's disease · 2025Article
- Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.NPJ Parkinson's disease · 2025Article
- Correlation between Parkinson's disease subtypes and plasma uric acid/neutrophil-to-lymphocyte ratio.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Towards scalable screening for the early detection of Parkinson's disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker.NPJ Parkinson's disease · 2025Article
- Biofeedback for Motor and Cognitive Rehabilitation in Parkinson's Disease: A Comprehensive Review of Non-Invasive Interventions.Brain sciences · 2025Review
- Negative emotion modulates postural tremor variability in Parkinson's disease: A multimodal EEG and motion sensor study toward behavioral interventions.IBRO neuroscience reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD). The progression and management of tremor in PD can be challenging, as response to dopaminergic agents might be relatively poor, particularly in patients with tremor-dominant PD compared to the akinetic/rigid subtype. In this review, we aim to highlight recent advances in the underlying pathogenesis and treatment modalities for tremor in PD. Methods: A structured literature search through Embase was conducted using the terms "Parkinson's Disease" AND "tremor" OR "etiology" OR "management" OR "drug resistance" OR "therapy" OR "rehabilitation" OR "surgery." After initial screening, eligible articles were selected with a focus on published literature in the last 10 years. Discussion: The underlying pathophysiology of tremor in PD remains complex and incompletely understood. Neurodegeneration of dopaminergic neurons in the retrorubral area, in addition to high-power neural oscillations in the cerebello-thalamo-cortical circuit and the basal ganglia, play a major role. Levodopa is the first-line therapeutic option for all motor symptoms, including tremor. The addition of dopamine agonists or anticholinergics can lead to further tremor reduction. Botulinum toxin injection is an effective alternative for patients with pharmacological-resistant tremor who are not seeking advanced therapies. Deep brain stimulation is the most well-established advanced therapy owing to its long-term efficacy, reversibility, and effectiveness in other motor symptoms and fluctuations. Magnetic resonance-guided focused ultrasound is a promising modality, which has the advantage of being incisionless. Cortical and peripheral electrical stimulation are non-invasive innovatory techniques that have demonstrated good efficacy in suppressing intractable tremor.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.