Evidence map›Paper›PMID 36213541›Full record

ReviewActa pharmaceutica Sinica. B2022

Extracellular vesicles: Emerging tools as therapeutic agent carriers.

Shan Liu, Xue Wu, Sutapa Chandra, Christopher Lyon, Bo Ning, Li Jiang, Jia Fan, Tony Y Hu

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Clinical Applications of Extracellular Vesicles: Promises and Pitfalls.International journal of molecular sciences · 2026
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Shan LiuSichuan Provincial Key Laboratory for Human Disease Gene Study, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Xue WuThe M.O.E. Key Laboratory of Laboratory Medical Diagnostics, the College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Sutapa ChandraDepartment of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Christopher LyonDepartment of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Bo NingDepartment of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Li JiangSichuan Provincial Key Laboratory for Human Disease Gene Study, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China.
Jia FanDepartment of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Tony Y HuDepartment of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnosis, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
Tulane University · USChongqing Medical University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids, and metabolites from donor to recipient cells in cell-to-cell communication. Some EV components can also indicate the type and biological status of their parent cells and serve as diagnostic targets for liquid biopsy. EVs can also natively carry or be modified to contain therapeutic agents (

Indexed as

Cancer therapyDelivery carrierExtracellular vesicleGene therapyInfectious disease vaccineOuter membrane vesicleRegenerative medicineTherapeutic agent

Identifiers

PMID36213541
PMCPMC9532556
OpenAlexW4280602680

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.