Evidence map›Paper›PMID 36213583›Full record

ArticleComputational and mathematical methods in medicine2022

Diagnostic Value of IGFBP-2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case-Control Study.

Fei Gao, Jiaye Yin, Yan Long, Sufei Zhu, Zhenting Huang, Jielin Wang, Hao Zheng, Wen Wang, Lei Zheng

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fei GaoThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.ORCID https://orcid.org/0000-0003-0719-2431
Jiaye YinDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Yan LongDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Sufei ZhuDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Zhenting HuangDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Jielin WangDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Hao ZhengDepartment of Laboratory, Guangzhou Women and Children's Medical Center, China.
Wen WangThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.ORCID https://orcid.org/0000-0002-6913-4731
Lei ZhengThe First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.ORCID https://orcid.org/0000-0003-2576-8780
Guangzhou Women and Children Medical Center · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To identify novel biomarker insulin-like growth factor binding protein-2 (IGFBP-2) associated with preeclampsia (PE) before 20 weeks of gestation and to explore the predictive value of plasma IGFBP-2 in PE. Methods: A prospective nested case-control investigation involving 122 PE patients and 122 normal controls (NC) that were matched 1 : 1 in terms of age and week of pregnancy was carried out in Guangzhou Women and Children's Medical Center (Guangzhou, China, 2018030306) from April 2016 to December 2019. At 8 to 20 weeks, blood samples from the mother were taken. To calculate the correlations, univariate conditional logistic regression was employed. Results: Herein, 12 clinical indices were significantly different between the PE and NC groups (uric acid (UA), cystatin C (Cys C), aspartate aminotransferase (AST), glutamyl transpeptidase ( Conclusion: Plasma IGFBP-2 before 20 weeks of pregnancy combined with high-risk factors and routine blood indexes has a high early predictive value for PE.

Indexed as

Pre-EclampsiaAspartate AminotransferasesBilirubinBiomarkersCase-Control StudiesCesarean SectionChildCystatin CFemalegamma-GlutamyltransferaseHumansInsulin-Like Growth Factor Binding Protein 2PregnancyProspective StudiesUric AcidAspartate AminotransferasesBilirubinBiomarkersCystatin Cgamma-GlutamyltransferaseInsulin-Like Growth Factor Binding Protein 2Uric Acid

Identifiers

PMID36213583
PMCPMC9534648
OpenAlexW4297516589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.