Evidence map›Paper›PMID 36214665›Full record

ArticleeLife2022

N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia.

Jong S Park, Austin M Gabel, Polina Kassir, Lois Kang, Prableen K Chowdhary, Afia Osei-Ntansah, Neil D Tran, Soujanya Viswanathan, Bryanna Canales, Pengfei Ding and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Clinical and Molecular Differences of Hypertensive Disorders During Pregnancy.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Insight into the Regulation of NDRG1 Expression.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jong S ParkDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.ORCID https://orcid.org/0000-0001-7989-4630
Austin M GabelDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Polina KassirDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Lois KangDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Prableen K ChowdharyDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Afia Osei-NtansahDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Neil D TranDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Soujanya ViswanathanDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Bryanna CanalesDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.
Pengfei DingDepartment of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, United States.
Young-Sam LeeDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Rachel BrewsterDepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, United States.ORCID https://orcid.org/0000-0002-9058-2045
University of Maryland, Baltimore County · USJohns Hopkins University · US

Funding

U-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5M
G-RISE at UMBCT32GM144876 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI Rachel Melissa Brewster, Robin Herlands Cresiski · 2022 to 2026
$5.8M
Signaling mechanisms that mediate anoxia-induced cellular arrestR21HD089476 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI BREWSTER, RACHEL MELISSA · 2018 to 2019
$432k
Howard Hughes Medical InstituteNICHD NIH HHS R21 HD089476NIGMS NIH HHS T32 GM144876NIGMS NIH HHS T34 GM136497
6 · The paper itself

Abstract

Lack of oxygen (hypoxia and anoxia) is detrimental to cell function and survival and underlies many disease conditions. Hence, metazoans have evolved mechanisms to adapt to low oxygen. One such mechanism, metabolic suppression, decreases the cellular demand for oxygen by downregulating ATP-demanding processes. However, the molecular mechanisms underlying this adaptation are poorly understood. Here, we report on the role of

Indexed as

HypoxiaZebrafishAdenosine TriphosphateAnimalsLactatesOxygenPotassiumSodiumSodium AzideSodium-Potassium-Exchanging ATPaseAdenosine TriphosphateLactatesOxygenPotassiumSodiumSodium AzideSodium-Potassium-Exchanging ATPaseanoxiacell biologydevelopmental biologyhypometabolismhypoxialactateNDRG1sodium-potassium pumpzebrafish

Identifiers

PMID36214665
PMCPMC9550225
OpenAlexW4303982350

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.