Evidence map›Paper›PMID 36214939›Full record

ArticleTranslational stroke research2023

cPKCγ-Modulated Autophagy Contributes to Ischemic Preconditioning-Induced Neuroprotection in Mice with Ischemic Stroke via mTOR-ULK1 Pathway.

Ying Zhang, Longhui Ma, Yi Yan, Li Zhao, Song Han, Di Wu, Cesar V Borlongan, Junfa Li, Xunming Ji

Abstract read
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In one paragraph

Article in Translational stroke research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ying ZhangDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China.
Longhui MaDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China.
Yi YanDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China.
Li ZhaoDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China.
Song HanDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China.
Di WuBeijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, 100053, China.
Cesar V BorlonganDepartment of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, 33612, USA.
Junfa LiDepartment of Neurobiology, Capital Medical University, #10 You An Men Wai Xi Tou Tiao, Fengtai District, Beijing, 100069, People's Republic of China. junfali@ccmu.edu.cn.ORCID 0000-0002-1930-9724
Xunming JiBeijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, 100053, China. jixm@ccmu.edu.cn.
Capital Medical University · CNUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuron-specific conventional protein kinase C (cPKC)γ mediates cerebral hypoxic preconditioning (HPC). In parallel, autophagy plays a prosurvival role in ischemic preconditioning (IPC) against ischemic stroke. However, the effect of cPKCγ on autophagy in IPC still remains to be addressed. In this study, adult and postnatal 1-day-old C57BL/6 J wild-type (cPKCγ

Indexed as

Brain IschemiaIschemic PreconditioningIschemic StrokeAnimalsAutophagyIschemiaMiceMice, Inbred C57BLNeuroprotectionTOR Serine-Threonine KinasesTOR Serine-Threonine KinasesAutophagyConventional protein kinase C (cPKC)γIschemic preconditioning (IPC)Ischemic strokemTOR-ULK1 signaling pathway

Identifiers

PMID36214939
OpenAlexW4303984168

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.