Evidence map›Paper›PMID 36218140›Full record

ArticleProtein science : a publication of the Protein Society2022

Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.

Angela Tramonti, Mohini S Ghatge, Jill T Babor, Faik N Musayev, Martino Luigi di Salvo, Anna Barile, Gianni Colotti, Alessandra Giorgi, Steven D Paredes, Akua K Donkor and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  4. Review
  5. The Substrate Versatility of ΔMolecules (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. The ubiquitous pyridoxal 5'-phosphate-binding protein is also an RNA-binding protein.Protein science : a publication of the Protein Society · 2024
    Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Angela TramontiIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Mohini S GhatgeInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Jill T BaborDepartment of Microbiology and Cell Science, University of Florida, Gainsville, Florida, USA.
Faik N MusayevInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Martino Luigi di SalvoIstituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.
Anna BarileIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Gianni ColottiIstituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy.
Alessandra GiorgiIstituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.
Steven D ParedesInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Akua K DonkorInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Mohammed H Al MughramInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainsville, Florida, USA.
Martin K SafoInstitute for Structural Biology, Drug Discovery and Development, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Roberto ContestabileIstituto Pasteur Italia-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Rome, Italy.ORCID 0000-0002-5235-9993
Virginia Commonwealth University · USInstitute of Molecular Biology and Pathology · ITIstituto Pasteur · ITUniversity of Florida · US

Funding

Pyridoxal 5'-phosphate homeostasis in Escherichia coliR01GM129793 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2019 to 2022
$1.2M
X-ray Crystallographic Data Collection SystemS10OD021756 · OD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAFO, MARTIN K · 2017 to 2017
$600k
NIGMS NIH HHS R01 GM129793NIH HHS S10 OD021756
6 · The paper itself

Abstract

The pyridoxal 5'-phosphate (PLP) homeostasis protein (PLPHP) is a ubiquitous member of the COG0325 family with apparently no catalytic activity. Although the actual cellular role of this protein is unknown, it has been observed that mutations of the PLPHP encoding gene affect the activity of PLP-dependent enzymes, B

Indexed as

Escherichia coliEscherichia coli ProteinsCarrier ProteinsHomeostasisLysinePhosphatesProteinsProtein StabilityPyridoxal PhosphateCarrier ProteinsEscherichia coli ProteinsLysinePhosphatesProteinsPyridoxal PhosphateYggS protein, E coliCOG0325 familyPLPHPpyridoxal 5′-phosphatevitamin B6YggS

Identifiers

PMID36218140
PMCPMC9601805
OpenAlexW4304185110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.