Observational studyAnnals of clinical biochemistry2023
The association between acid-base status and clinical outcome in critically ill COVID-19 patients admitted to intensive care unit with an emphasis on high anion gap metabolic acidosis.
Observational study in Annals of clinical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- A retrospective clinical risk prediction model for co‑infection with Mycoplasma pneumoniae in patients with COVID‑19 based on restricted cubic splines.Scientific reports · 2026Article
- Rising mortality from electrolyte and acid-base imbalances in the United States (1999-2020): a joinpoint regression analysis of national trends and disparities.Annals of medicine and surgery (2012) · 2026Review
- Non-linear association between anion gap and 28-day mortality in critically ill patients with COVID-19: a cohort study from MIMIC IV database.Journal of thoracic disease · 2025Article
- Risk factors affecting the development of pneumothorax in patients followed up in intensive care with a diagnosis of COVID-19.BMC infectious diseases · 2024Observational
- Association between serum anion gap and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database.BMC cardiovascular disorders · 2024Article
- Association between the anion gap and mortality in critically ill patients with influenza: A cohort study.Heliyon · 2024Article
- [Acid-base balance and long COVID: comments on metabolic-respiratory alterations].Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2023Article
- Evaluation of the Acid-Base Status in Patients Admitted to the ICU Due to Severe COVID-19: Physicochemical versus Traditional Approaches.Journal of personalized medicine · 2023Article
- Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways.Pharmaceutics · 2023Article
- Acid-base imbalance as a risk factor for mortality among COVID-19 hospitalized patients.Bioscience reports · 2023Article
- Immunologic and vascular biomarkers of mortality in critical COVID-19 in a South African cohort.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to identify arterial blood gas (ABG) abnormalities, with a focus on a high anion gap (AG) metabolic acidosis and evaluate outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU.
methodsA retrospective, observational study was conducted in a tertiary hospital in Cape Town during the first and second COVID-19 waves. Age, gender, sodium (Na), potassium (K), chloride (Cl), bicarbonate (HCO
resultsThis study included 465 patients, 226 (48%) of whom were female. The sample population's median (IQR) age was 54.2 (46.1-61.3) years, and 63% of the patients died. ABG analyses found that 283 (61%) of the 465 patients had alkalosis (pH ≥ 7.45), 65 (14%) had acidosis (pH ≤ 7.35) and 117 (25%) had normal pH (7.35-7.45). In the group with alkalosis, 199 (70.3%) had a metabolic alkalosis and in the group with acidosis, 42 (64%) had a metabolic acidosis with an increased AG of more than 17. Non-survivors were older than survivors (56.4 years versus 50.3 years,
conclusionMost of the COVID-19 patients admitted to the ICU had an alkalosis, and those with acidosis had a much worse prognosis. Higher AG metabolic acidosis was not associated with patients' characteristics.
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