ArticleJMIR mental health2022
A Digital Intervention Using Daily Financial Incentives to Increase Medication Adherence in Severe Mental Illness: Single-Arm Longitudinal Pilot Study.
Article in JMIR mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04191876 (Financial Incentives to Improve Medication Adherence), which is not on this map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Financial Incentives to Improve Medication Adherence: a Pilot Study
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Telehealth and Pharmacotherapy: The Role of Synchronous and Novel Asynchronous Digital Health Tools in Psychiatry.Pharmaceutical medicine · 2025Review
- Financial incentives and long-acting injectable antipsychotics engagement: community mental health professionals' perspectives.BMC psychiatry · 2025Article
- Randomized clinical trial of a digital medication system to enhance adherence in patients with severe mental disorders.NPJ digital medicine · 2025Article
- The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pilot randomized controlled trial.NPP - digital psychiatry and neuroscience · 2025Article
- Article
- On the Road to Individualizing Pharmacotherapy for Adolescents and Adults with Schizophrenia - Results from an Expert Consensus Following the Delphi Method.Neuropsychiatric disease and treatment · 2024Article
- Digital health interventions to improve adherence to oral antipsychotics among patients with schizophrenia: a scoping review.BMJ open · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedication nonadherence is prevalent in severe mental illness and is associated with multiple negative outcomes. Mobile technology and financial incentives show promise to improve medication adherence; however, studies in mental health, especially with oral medications, are lacking.
objectiveThe aim of this paper is to assess the feasibility and effectiveness of offering financial incentives through a mobile app based on behavioral economics principles to improve medication adherence in severe mental illness.
methodsA 10-week, single-arm longitudinal pilot study was conducted. Patients earned rewards in the context of app-based adherence incentives. The reward was split into biweekly payments made in increments of US $15, minus any US $2 per day penalties for missed check-ins. Time-varying effect modeling was used to summarize the patients' response during the study.
resultsA total of 25 patients were enrolled in this pilot study, of which 72% (n=18) were female, and 48% (n=12) were of a White racial background. Median age was 24 (Q1-Q3: 20.5-30) years. Participants were more frequently diagnosed with schizophrenia and related disorders (n=9, 36%), followed by major depressive disorder (n=8, 32%). App engagement and medication adherence in the first 2 weeks were higher than in the last 8 weeks of the study. At study endpoint, app engagement remained high (n=24, Z=-3.17; P<.001), but medication adherence was not different from baseline (n=24, Z=-0.59; P=.28).
conclusionsFinancial incentives were effectively delivered using an app and led to high engagement throughout the study and a significantly increased medication adherence for 2 weeks. Leveraging behavioral economics and mobile health technology can increase medication adherence in the short term.
trial registrationClinicalTrials.gov NCT04191876; https://clinicaltrials.gov/ct2/show/NCT04191876.
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