ArticleNeurology2023
Menopausal Vasomotor Symptoms and White Matter Hyperintensities in Midlife Women.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Risk factors, management and consequences of severe menopausal vasomotor symptoms.Nature reviews. Endocrinology · 2026Review
- Evidence of APOE4-related brain vulnerabilities in verbal memory systems in midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Women's midlife: the front line of Alzheimer prevention.The Journal of clinical investigation · 2026Review
- Article
- Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer's disease risk.Research square · 2026Article
- Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer's disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Association Between Vasomotor Symptoms and Ischemic Stroke: A Case-Control Study.Brain and behavior · 2025Article
- The proportion of plant-based food consumption during midlife and cognitive health in later life in Australian women: data from the Women's Healthy Ageing Project (WHAP).European journal of nutrition · 2025Article
- Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Menopause is a Whole-Person Developmental Transition: An Overview of Menopause Information and Acupuncture Therapy Approaches to Symptom Management.Medical acupuncture · 2025Article
- Improving Cardiovascular Clinical Competencies for the Menopausal Transition: A Focus on Cardiometabolic Health in Midlife.JACC. Advances · 2025Article
- One size does not fit all: how type of menopause and hormone therapy matters for brain health.The British journal of psychiatry : the journal of mental science · 2025Review
- Reproductive hormones in relation to white matter hyperintensity volumes among midlife women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Risks and benefits of hormone therapy after menopause for cognitive decline and dementia: A conceptual review.Maturitas · 2024Review
- Higher HbA1c Is Associated With Greater 2-Year Progression of White Matter Hyperintensities.Diabetes · 2024Article
- Trauma and its implications for women's cardiovascular health during the menopause transition: Lessons from MsHeart/MsBrain and SWAN studies.Maturitas · 2024Review
- Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers.American journal of obstetrics and gynecology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesThe menopause transition is increasingly recognized as a time of importance for women's brain health. A growing body of work indicates that the classic menopausal symptom, vasomotor symptom (VMS), may be associated with poorer cardiovascular health. Other work links VMS to poorer cognition. We investigate whether VMS, when rigorously assessed using physiologic measures, are associated with greater white matter hyperintensity volume (WMHV) among midlife women. We consider a range of potential explanatory factors in these associations and explore whether VMS are associated with the spatial distribution of WMHV.
methodsWomen aged 45-67 years and free of hormone therapy underwent 24 hours of physiologic VMS monitoring (sternal skin conductance), actigraphy assessment of sleep, physical measures, phlebotomy, and 3 Tesla neuroimaging. Associations between VMS (24-hour, wake, and sleep VMS, with wake and sleep intervals defined by actigraphy) and whole brain WMHV were considered in linear regression models adjusted for age, race, education, smoking, body mass index, blood pressure, insulin resistance, and lipids. Secondary models considered WMHV in specific brain regions (deep, periventricular, frontal, temporal, parietal, and occipital) and additional covariates including sleep.
resultsThe study sample included 226 women. Physiologically assessed VMS were associated with greater whole brain WMHV in multivariable models, with the strongest associations observed for sleep VMS (24-hour VMS, B[SE] = 0.095 [0.045], DISCUSSION: VMS, particularly VMS occurring during sleep, were associated with greater WMHV. Identification of female-specific midlife markers of poor brain health later in life is critical to identify women who warrant early intervention and prevention. VMS have the potential to serve as female-specific midlife markers of brain health in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.