ReviewReviews in endocrine & metabolic disorders2023
Iodine status and supplementation in pregnancy: an overview of the evidence provided by meta-analyses.
Review in Reviews in endocrine & metabolic disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07579988 (Ultrasound Measurement of Thyroid Volume in Term Newborns), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound Measurement of Thyroid Volume in Term Newborns : a Single-centre Cross Sectional Observational Study
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dairy Intake and Iodine Status in Pregnant and Lactating Women: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- Urinary Iodine and Maternal Thyroid Hormones Across Pregnancy Trimesters: a Stratified and Nonlinear Analysis from 2020-2024.Biological trace element research · 2026Article
- Iodine and Its Impact on the Immune System of Humans and Domesticated Mammals: A Narrative Review.Nutrients · 2026Review
- Effects of per- and polyfluoroalkyl substances on maternal thyroid function: a stratified analysis by maternal iodine status and thyroid autoantibody status.BMC pregnancy and childbirth · 2026Article
- Nutrition, Physical Activity and Other Health Aspects Before and During Pregnancy - Recommendations by the Nationwide "Healthy Start Network" (Netzwerk Gesund ins Leben) 2026.Geburtshilfe und Frauenheilkunde · 2026Article
- Iodine in Health and Disease: A Comprehensive Review.Nutrients · 2026Review
- Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026Article
- Adherence to vitamin and dietary supplement intake in fertility and pregnancy care: insights into knowledge, information satisfaction, and formulation variability.Archives of gynecology and obstetrics · 2026Article
- The relationship between social support and dietary salt choices among pregnant women in Hangzhou: a cross-sectional study.Frontiers in public health · 2026Article
- Stage-specific variations in urinary and salt iodine among pregnant women in Beijing.Frontiers in nutrition · 2026Article
- Beyond Calories: Addressing Micronutrient Deficiencies in the World's Most Vulnerable Communities-A Review.Nutrients · 2025Review
- Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study.Advances in nutrition (Bethesda, Md.) · 2025Article
- Should iodine supplementation be universally recommended for pregnant women in Brazil? A position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM).Archives of endocrinology and metabolism · 2025Review
- Thyroid and female fertility: a survey on the clinical practice among endocrinologists belonging to the italian thyroid association.Journal of endocrinological investigation · 2025Article
- Overview of thyroid disorders in pregnancy.Maternal health, neonatology and perinatology · 2025Review
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- Impact of iodine nutritional levels in urban and rural pregnant women on neonatal growth indicators: a cohort study in Xinjiang, China.Frontiers in nutrition · 2025Article
- Effects of endocrine disruptors on thyroid function: consequences of fetal exposure.Turkish journal of medical sciences · 2025Review
- Modern challenges of iodine nutrition: vegan and vegetarian diets.Frontiers in endocrinology · 2025Review
- Changes in Central Sensitivity to Thyroid Hormones vs. Urine Iodine during Pregnancy.Medical sciences (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iodine supplementation during pregnancy in areas with mild-moderate deficiency is still a matter of debate. The present study aimed at systematically reviewing currently available evidences provided by meta-analyses with the aim to further clarify controversial aspects regarding the need of iodine supplementation in pregnancy as well as to provide guidance on clinical decision-making, even in areas with mild-moderate deficiency. Medline, Embase and Cochrane search from 1969 to 2022 were performed. For the purpose of this review, only studies containing meta-analytic data were selected. A total of 7 meta-analyses were retrieved. Four meta-analyses evaluated the relationship between iodine status during pregnancy and neonatal and maternal outcomes suggesting the existence of a U-shaped correlation between iodine status and several maternal and neonatal consequences, especially if iodine status is evaluated at the beginning of pregnancy. Three meta-analyses evaluating the results of intervention trials failed to provide straightforward conclusions on the benefits of iodine supplementation in pregnant women in areas with mild-moderate iodine deficiency. Although evidence coming from meta-analyses suggests a role of iodine status during pregnancy in determining maternal and child outcomes, results of meta-analyses of intervention trials are still controversial. Several factors including, degree of iodine deficiency, and pooling studies conducted in areas with different iodine intake, may account for the lack of benefits reported by meta-analyses of intervention trials. More high-quality, randomized, controlled trials including information on timing, dose and regimen of iodine supplementation are needed to further elucidate this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.