Evidence map›Paper›PMID 36230592›Full record

ReviewCancers2022

Optimizing the Choice for Adjuvant Chemotherapy in Gastric Cancer.

Antonino Grassadonia, Antonella De Luca, Erminia Carletti, Patrizia Vici, Francesca Sofia Di Lisa, Lorena Filomeno, Giuseppe Cicero, Laura De Lellis, Serena Veschi, Rosalba Florio and 4 more

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Thromboembolic events in patients who received adjuvant chemotherapy for gastric cancer: a single-center retrospective study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Antonino GrassadoniaDepartment of Innovative Technologies in Medicine and Dentistry, and Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2459-0661
Antonella De LucaDepartment of Medical, Oral and Biotechnological Sciences, and Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.
Erminia CarlettiDepartment of Medical, Oral and Biotechnological Sciences, and Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.
Patrizia ViciUnit of Phase IV Trials, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Francesca Sofia Di LisaUnit of Phase IV Trials, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Lorena FilomenoUnit of Phase IV Trials, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Giuseppe CiceroDepartment of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90133 Palermo, Italy.
Laura De LellisDepartment of Pharmacy, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-6460-2508
Serena VeschiDepartment of Pharmacy, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-0450-9210
Rosalba FlorioDepartment of Pharmacy, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-3095-1451
Davide BroccoDepartment of Pharmacy, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-8634-7184
Saverio AlbertiUnit of Medical Genetics, Department of Biomedical Sciences-BIOMORF, University of Messina, 98125 Messina, Italy.
Alessandro CamaDepartment of Pharmacy, G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-3647-1368
Nicola TinariDepartment of Medical, Oral and Biotechnological Sciences, and Center for Advanced Studies and Technology (CAST), G. D'Annunzio University Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-8449-5407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in the management of gastric cancer have improved patient survival in the last decade. Nonetheless, the number of patients relapsing and dying after a diagnosis of localized gastric cancer is still too high, even in early stages (10% in stage I). Adjuvant systemic chemotherapy has been proven to significantly improve outcomes. In the present article we have critically reviewed the clinical trials that guide the current clinical practice in the adjuvant treatment of patients affected by resectable gastric cancer, focusing on the different approaches worldwide, i.e., adjuvant chemotherapy, adjuvant chemoradiotherapy, and perioperative chemotherapy. We also delineate the clinical-pathological characteristics that are commonly taken into account to identify patients at a higher risk of recurrence and requiring adjuvant chemotherapy, and also describe novel biomarkers and therapeutic agents that might allow personalization of the treatment.

Indexed as

adjuvant chemotherapygastric cancerpredictive factorsprognostic factors

Identifiers

PMID36230592
PMCPMC9563297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.