ArticleCancers2022
The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
- Formononetin attenuates ethanol-induced gastric ulcer injury by targeting ALDH2 to inhibit oxidative stress.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Gastrin-dependent expansion of Cck2rGut · 2026Article
- Factors Associated with Malignant Gastric Ulcers: A 10-year Retrospective Cohort Study.International journal of general medicine · 2026Article
- Development and validation of a nomogram incorporating dietary factors for predictingWorld journal of gastroenterology · 2025Article
- An overview of hepatitis B virus in gastric carcinogenesis: from clinical association to molecular mechanisms.Infectious agents and cancer · 2025Review
- Nuclear magnetic resonance-based metabolomics and risk of pancreatic cancer: a prospective analysis in the UK Biobank.Journal of gastroenterology · 2025Article
- The Role of Triterpenoids in Gastric Ulcer: Mechanisms and Therapeutic Potentials.International journal of molecular sciences · 2025Review
- Integrating Salivary Biomarkers CST4 andClinical Medicine Insights. Oncology · 2025Article
- Cancer prevalence and its determinants in Hungary: Analyzing data from the 2009, 2014, and 2019 European Health Interview Surveys.PloS one · 2025Article
- Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis.BMC medicine · 2024Article
- Risk factors for peptic ulcer bleeding one year after the initial episode.Gut pathogens · 2024Article
- Association between the consumption of ultra-processed foods and the incidence of peptic ulcer disease in the SUN project: a Spanish prospective cohort study.European journal of nutrition · 2024Article
- The global gastric cancer consortium: an update from the Stomach cancer Pooling (StoP) project.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2024Article
- Gastrointestinal Tract Cancers, an Increasing Burden of the Modern Era: Epidemiology and Prevention.Cancers · 2023Article
- Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil.Nutrients · 2023Article
- Epidemiology of Gastric Cancer: Global Trends, Risk Factors and Premalignant Conditions.Journal of community hospital internal medicine perspectives · 2023Review
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Authors and funding
32 authors at 20 institutions in 11 countries.
Funding
Abstract
backgroundGastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by
methodsHistory of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth's penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC.
resultsHistory of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07-4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77-1.39).
conclusionsIn the pooled analysis of 11 case-control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.