Evidence map›Paper›PMID 36232671›Full record

ArticleInternational journal of molecular sciences2022

Functional and Expressional Analyses Reveal the Distinct Role of Complement Factor I in Regulating Complement System Activation during GCRV Infection in

Yi Liu, Zhao Lv, Tiaoyi Xiao, Xuewen Zhang, Chunhua Ding, Beibei Qin, Baohong Xu, Qiaolin Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Updating Our Knowledge on Fish Immunology.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yi LiuHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-1247-1251
Zhao LvHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.ORCID 0000-0002-3539-6661
Tiaoyi XiaoHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Xuewen ZhangHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Chunhua DingHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Beibei QinHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Baohong XuHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Qiaolin LiuHunan Engineering Technology Research Center of Featured Aquatic Resources Utilization, Hunan Agricultural University, Changsha 410128, China.
Hunan Agricultural University · CN

Funding

National Natural Science Foundation of China 31972787National Natural Science Foundation of China U20A2063Natural Science Foundation of Hunan Province 2021JJ40244the Key Scientific Research Project of Education Department of Hunan Province 20A243
6 · The paper itself

Abstract

Complement factor I (CFI), a complement inhibitor, is well known for regulating the complement system activation by degrading complement component 3b (C3b) in animal serum, thus becoming involved in innate defense. Nevertheless, the functional mechanisms of CFI in the complement system and in host-pathogen interactions are far from being clarified in teleost fish. In the present study, we cloned and characterized the CFI gene, CiCFI, from grass carp (

Indexed as

CarpsFish DiseasesReoviridaeReoviridae InfectionsAmino AcidsAnimalsComplement ActivationComplement C3bComplement Factor DComplement Factor IComplement Inactivating AgentsFish ProteinsGene Expression RegulationMammalsPhylogenyRNA, MessengerAmino AcidsComplement C3bComplement Factor DComplement Factor IComplement Inactivating AgentsFish ProteinsRNA, Messengercomplement component 3bcomplement factor Icomplement regulation mechanismgrass carpgrass carp reovirus infection

Identifiers

PMID36232671
PMCPMC9569754
OpenAlexW4297539709

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.